@article{fdi:010064778,
  title = {{E}fficacy of praziquantel against urinary schistosomiasis and reinfection in {S}enegalese school children where there is a single well-defined transmission period},
  author = {{S}enghor, {B}. and {D}iaw, {O}. {T}. and {D}oucour{\'e}, {S}. and {S}ylla, {S}. {N}. and {S}eye, {M}. and {T}alla, {I}. and {B}a, {C}. {T}. and {D}iallo, {A}. and {S}okhna, {C}heikh},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {H}uman schistosomiasis is a significant health problem in {S}ub-{S}aharan {A}frica. {I}n {N}iakhar, {W}est central {S}enegal, the transmission of {S}. haematobium occurs seasonally between {J}uly and {N}ovember. {N}o control measures have been implemented despite high prevalence reported in previous studies. {T}his aim of this study was to i) determine the current prevalence of {S}. haematobium in children at {N}iakhar, ii) assess the efficacy of one dose of {PZQ} (40 mg/kg) against {S}. haematobium and iii) monitor reinfection. {M}ethods: {T}he current study was carried out in a cohort of 329 children aged five to 15 years enrolled from six villages in {N}iakhar to determine the efficacy of one dose of {PZQ}, as well as reinfection. {P}arasitological screening was performed in {J}une 2011 to determine the baseline prevalence of {S}. haematobium, and then a single dose of {PZQ} was administered to all selected subjects in the transmission season in {A}ugust 2011. {T}he efficacy of {PZQ} treatment and reinfection were monitored respectively five weeks after in {S}eptember 2011 and from {F}ebruary to {M}arch 2012. {R}esults: {A}t baseline, the overall prevalence and the heavy intensity of infection were 73.2 % and 356.1eggs/10 ml of urine. {S}ignificant differences in the prevalence and intensity of {S}. haematobium infection were noted between villages. {A} single dose of {PZQ} significantly reduced the prevalence of {S}. haematobium infection from 73.2 % to 4.6 % and the geometric mean intensity of infection from 356.1 to 43.3 eggs/10 ml of urine. {T}he cure rates ranged from 89.4 % to 100 %. {T}he egg reduction rates also ranged from 77.6 % to 100 %. {T}wo to three months after the period of transmission, the overall rate of reinfection was 12.6 % and was significantly higher in male children than in female children. {T}he overall prevalence at this period was 13.8 %, which was significantly lower than the prevalence at baseline (73.2 %). {C}onclusion: {T}he {N}iakhar study area remains a hot spot of urinary schistosomiasis in {S}enegal with differences in transmission between villages. {T}his study suggests that when transmission is strictly seasonal, {P}raziquantel shows the expected efficacy in reducing the prevalence and intensity of infection, but also a significant effect on the occurrence of reinfection.},
  keywords = {{U}rinary schistosomiasis ; {S}easonal transmission ; {P}raziquantel treatment ; {R}einfection ; {N}iakhar ; {S}enegal ; {SENEGAL}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {8},
  numero = {},
  pages = {art. 362 [11 ]},
  ISSN = {1756-3305},
  year = {2015},
  DOI = {10.1186/s13071-015-0980-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064778},
}