@article{fdi:010064753,
  title = {{T}he {A}nopheles gambiae c{E}5 salivary protein : a sensitive biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control},
  author = {{M}arie, {A}. and {R}onca, {R}. and {P}oinsignon, {A}nne and {L}ombardo, {F}. and {D}rame, {P}. {M}. and {C}orn{\'e}lie, {S}ylvie and {B}esnard, {P}. and {L}e {M}ire, {J}. and {F}iorentino, {G}. and {F}ortes, {F}. and {C}arnevale, {P}ierre and {R}emou{\'e}, {F}ranck and {A}rca, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}valuation of vector control is crucial for improving malaria containment and, according to {W}orld {H}ealth {O}rganization, new complementary indicators would be very valuable. {I}n this study the {I}g{G} response to the {A}nopheles-specific c{E}5 salivary protein was tested as a tool to evaluate the efficacy of insecticide-treated nets in reducing human exposure to malaria vectors. {S}era collected during a longitudinal study carried out in {A}ngola, and including entomological and parasitological data, were used to assess the {I}g{G} response to the {A}nopheles gambiae c{E}5 in both children and adults, before and after the application of insecticide-treated nets. {S}easonal fluctuation of specific {I}g{G} antibody levels according to exposure was only found in children (up to approximate to 14 years old) whose anti-c{E}5 {I}g{G} response dropped after bed nets installation. {T}hese results were fully consistent with previous findings obtained with the same set of sera and indicating a substantial reduction of human-vector contact shortly after nets implementation. {O}verall, children {I}g{G} response to the c{E}5 protein appeared a very sensitive biomarker, which allowed for the detection of even weak exposure to {A}nopheles bites, indicating it may represent a reliable additional tool to evaluate the efficacy of vector control interventions.},
  keywords = {c{E}5 salivary protein ; {A}nopheles gambiae ; {M}alaria ; {B}iomarker ; {V}ector exposure ; {I}nsecticide-treated nets ; {ANGOLA}},
  booktitle = {},
  journal = {{M}icrobes and {I}nfection},
  volume = {17},
  numero = {6},
  pages = {409--416},
  ISSN = {1286-4579},
  year = {2015},
  DOI = {10.1016/j.micinf.2015.01.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064753},
}