@article{fdi:010064655,
  title = {{R}esistance to normal human serum reveals {T}rypanosoma lewisi as an underestimated human pathogen},
  author = {{L}un, {Z}. {R}. and {W}en, {Y}. {Z}. and {U}zureau, {P}. and {L}ecordier, {L}. and {L}ai, {D}. {H}. and {L}an, {Y}. {G}. and {D}esquesnes, {M}. and {G}eng, {G}. {Q}. and {Y}ang, {T}. {B}. and {Z}hou, {W}. {L}. and {J}annin, {J}. {G}. and {S}imarro, {P}. {P}. and {T}ruc, {P}hilippe and {V}incendeau, {P}. and {P}ays, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman-infectious trypanosomes such as {T}rypanosoma cruzi, {T}. brucei rhodesiense, and {T}. b. gambiense can be discriminated from those only infecting animals by their resistance to normal human serum ({NHS}). {T}hese parasites are naturally resistant to trypanolysis induced by the human-specific pore-forming serum protein apolipoprotein {L}1 ({A}po{L}-1). {T}. lewisi, a worldwide distributed parasite, has been considered as rat-specific and non-pathogenic to the natural hosts. {H}ere we provide evidence that 19 tested {T}. lewisi isolates from {T}hailand and {C}hina share resistance to {NHS}. {F}urther investigation on one selected isolate {CPO}02 showed that it could resist at least 90% {NHS} or 30 mu g/ml recombinant human {A}po{L}-1 (rh{A}po{L}-1) in vitro, in contrast to {T}. b. brucei which could not survive in 0.0001% {NHS} and 0.1 mu g/ml rh{A}po{L}-1. {I}n vivo tests in rats also demonstrated that this parasite is fully resistant to lysis by {NHS}. {T}ogether with recent reports of atypical human infection by {T}. lewisi, these data allow the conclusion that {T}. lewisi is potentially an underestimated and thus a neglected human pathogen.},
  keywords = {{T}rypanosome lewisi ; {N}ormal human serum ; {A}polipoprotein {L}-1 ; {T}rypanolysis ; {THAILANDE} ; {CHINE}},
  booktitle = {},
  journal = {{M}olecular and {B}iochemical {P}arasitology},
  volume = {199},
  numero = {1-2},
  pages = {58--61},
  ISSN = {0166-6851},
  year = {2015},
  DOI = {10.1016/j.molbiopara.2015.03.007},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064655},
}