%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Badiou, S.
%A Cournil, Amandine
%A Toubal, S.
%A Bargnoux, A. S.
%A Dupuy, A. M.
%A Fernandez, C.
%A Peyriere, H.
%A Reynes, J.
%A Cristol, J. P.
%T Long term reference change value of creatinine in HIV-positive patients with anti-retroviral therapy : a new tool in clinical practice
%D 2015
%L fdi:010064651
%G ENG
%J Clinical Biochemistry
%@ 0009-9120
%K Creatinine ; HIV ; Ritonavir ; Reference change value ; Renal ; tenofovir
%K FRANCE
%M ISI:000355213600013
%N 9
%P 622-624
%R 10.1016/j.clinbiochem.2015.01.002
%U https://www.documentation.ird.fr/hor/fdi:010064651
%> https://www.documentation.ird.fr/intranet/publi/2015/06/010064651.pdf
%V 48
%W Horizon (IRD)
%X Background: The use of reference change value (RCV) instead of reference interval emerged as an alternative approach for longitudinal interpretation of biological marker. Follow-up of creatinine variation in HIV-positive adults remains a challenge in order to prevent renal complications. Objectives: To determine the long term RCV of creatinine in HIV-positive adults receiving anti-retroviral therapy (ART) according to the use of tenofovir or ritonavir. Design and methods: Longitudinal study of 24 months that include 124 HIV-positive patients followed in HIV outpatient unit. Plasma creatinine was measured at 0, 6, 12 and 24 months in order to calculate the RCV. Results: In the whole group, a 24-month RCV of creatinine was 22.5%. Whatever the ART, the index of individuality was <0.6. Significantly higher RCV of creatinine was observed in patients receiving the association tenofovir and ritonavir (28%) compared to the patients receiving i) tenofovir without ritonavir (21.9%), ii) no tenofovir but ritonavir (22.2%), and iii) no tenofovir and no ritonavir (19.7%). Conclusions: The low value of index of individuality pinpointed that RCV should be used to identify critical change in serial creatinine results in HIV-positive adults. RCV of creatinine under ART was around 20% but reached 28% in case of association of tenofovir and ritonavir.
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