@article{fdi:010064651,
  title = {{L}ong term reference change value of creatinine in {HIV}-positive patients with anti-retroviral therapy : a new tool in clinical practice},
  author = {{B}adiou, {S}. and {C}ournil, {A}mandine and {T}oubal, {S}. and {B}argnoux, {A}. {S}. and {D}upuy, {A}. {M}. and {F}ernandez, {C}. and {P}eyriere, {H}. and {R}eynes, {J}. and {C}ristol, {J}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he use of reference change value ({RCV}) instead of reference interval emerged as an alternative approach for longitudinal interpretation of biological marker. {F}ollow-up of creatinine variation in {HIV}-positive adults remains a challenge in order to prevent renal complications. {O}bjectives: {T}o determine the long term {RCV} of creatinine in {HIV}-positive adults receiving anti-retroviral therapy ({ART}) according to the use of tenofovir or ritonavir. {D}esign and methods: {L}ongitudinal study of 24 months that include 124 {HIV}-positive patients followed in {HIV} outpatient unit. {P}lasma creatinine was measured at 0, 6, 12 and 24 months in order to calculate the {RCV}. {R}esults: {I}n the whole group, a 24-month {RCV} of creatinine was 22.5%. {W}hatever the {ART}, the index of individuality was <0.6. {S}ignificantly higher {RCV} of creatinine was observed in patients receiving the association tenofovir and ritonavir (28%) compared to the patients receiving i) tenofovir without ritonavir (21.9%), ii) no tenofovir but ritonavir (22.2%), and iii) no tenofovir and no ritonavir (19.7%). {C}onclusions: {T}he low value of index of individuality pinpointed that {RCV} should be used to identify critical change in serial creatinine results in {HIV}-positive adults. {RCV} of creatinine under {ART} was around 20% but reached 28% in case of association of tenofovir and ritonavir.},
  keywords = {{C}reatinine ; {HIV} ; {R}itonavir ; {R}eference change value ; {R}enal ; tenofovir ; {FRANCE}},
  booktitle = {},
  journal = {{C}linical {B}iochemistry},
  volume = {48},
  numero = {9},
  pages = {622--624},
  ISSN = {0009-9120},
  year = {2015},
  DOI = {10.1016/j.clinbiochem.2015.01.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064651},
}