@article{fdi:010064647,
  title = {{D}ebromokeramadine from the marine sponge {A}gelas cf. mauritiana : isolation and short regioselective and flexible synthesis},
  author = {{S}chroif-{G}regoire, {C}. and {A}ppenzeller, {J}. and {D}ebitus, {C}{\'e}cile and {Z}aparucha, {A}. and {A}l-{M}ourabit, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he debromokeramadine (2a), which was isolated from the {P}acific sponge {A}gelcis cf. mauritiana, is described in this manuscript. {W}e also report the synthesis of the debromokeramadine (2a) and its known brominated analog, keramadine (1), based on the regioselective oxidative addition of a guanidine derivative on {N}-acylpyrrole dihydropyridines. {T}his flexible approach was applied to the preparation of three debromo-analogs 2b-d by varying the substitution of the guanidine bis-nucleophile. {T}he reaction is a great progress for the regio-and stereoselective synthesis of debromokeramadine (2a) analogs and interesting library of pyrrole-2-aminoimidazole allowing biological activity studies.},
  keywords = {{D}ebromokeramadine ; {K}eramadine ; {P}yrrole ; {N}-{M}ethylimidazole ; {S}ponge ; {M}arine metabolite ; {SALOMON}},
  booktitle = {},
  journal = {{T}etrahedron},
  volume = {71},
  numero = {22},
  pages = {3609--3613},
  ISSN = {0040-4020},
  year = {2015},
  DOI = {10.1016/j.tet.2014.12.081},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064647},
}