@article{fdi:010064471,
  title = {{E}arly biting and insecticide resistance in the malaria vector {A}nopheles might compromise the effectiveness of vector control intervention in {S}outhwestern {U}ganda},
  author = {{O}juka, {P}. and {B}oum, {Y}. and {D}enoeud {N}dam, {L}. and {N}abasumba, {C}. and {M}uller, {Y}. and {O}kia, {M}. and {M}wanga-{A}mumpaire, {J}. and {B}eaudrap, {P}ierre de and {P}rotopopoff, {N}. and {E}tard, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {S}outhwestern {U}ganda has high malaria heterogeneity despite moderate vector control and other interventions. {M}oreover, the early biting transmission and increased resistance to insecticides might compromise strategies relying on vector control. {C}onsequently, monitoring of vector behaviour and insecticide efficacy is needed to assess the effectiveness of strategies aiming at malaria control. {T}his eventually led to an entomological survey in two villages with high malaria prevalence in this region. {M}ethods: {D}uring rainy, 2011 and dry season 2012, mosquitoes were collected in {E}ngari and {K}igorogoro, {K}azo subcounty, using human landing collection, morning indoor resting collection, pyrethrum spray collection and larval collection. {C}ircumsporozoite protein of {P}lasmodium falciparum sporozoites in female {A}nopheles mosquitoes was detected using {ELISA} assay. {B}ioassays to monitor {A}nopheles resistance to insecticides were performed. {R}esults: {O}f the 1,021 female {A}nopheles species captured, 62% (632) were {A}nopheles funestus and 36% (371) were {A}nopheles gambiae s.l. {T}he most common species were {A}nopheles gambiae s.l. in {E}ngari (75%) and {A}. funestus in {K}igorogoro (83%). {O}verall, {P}. falciparum prevalence was 2.9% by {ELISA}. {T}he daily entomological inoculation rates were estimated at 0.17 and 0.58 infected bites/person/night during rainy and dry season respectively in {E}ngari, and 0.81 infected bites/person/night in {K}igorogoro during dry season. {I}n both areas and seasons, an unusually early evening biting peak was observed between 6 - 8 p.m. {I}n {E}ngari, insecticide bioassays showed 85%, 34% and 12% resistance to {DDT} during the rainy season, dry season and to deltamethrin during the dry season, respectively. {I}n {K}igorogoro, 13% resistance to {DDT} and to deltamethrin was recorded. {T}here was no resistance observed to bendiocarb and pirimiphos methyl. {C}onclusions: {T}he heterogeneity of mosquito distribution, entomological indicators and resistance to insecticides in villages with high malaria prevalence highlight the need for a long-term vector control programme and monitoring of insecticide resistance in {U}ganda. {T}he early evening biting habits of {A}nopheles combined with resistance to {DDT} and deltamethrin observed in this study suggest that use of impregnated bed nets alone is insufficient as a malaria control strategy, urging the need for additional interventions in this area of high transmission.},
  keywords = {{PALUDISME} ; {VECTEUR} ; {MOUSTIQUE} ; {LUTTE} {CHIMIQUE} ; {INSECTICIDE} {CHIMIQUE} ; {RESISTANCE} ; {COMPORTEMENT} ; {VILLAGE} ; {DDT} ; {DELTAMETHRINE} ; {BENDIOCARB} ; {PRIMIPHOS} {METHYL} ; {OUGANDA} ; {ENGARI} ; {KIGOROGORO}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {14},
  numero = {},
  pages = {art. 148 [8 ]},
  ISSN = {1475-2875},
  year = {2015},
  DOI = {10.1186/s12936-015-0653-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064471},
}