Moussiliou A., Alao M. J., Denoeud Ndam Lise, Tahar Rachida, Ezimegnon S., Sagbo G., Amoussou A., Luty Adrian, Deloron Philippe, Tuikue Ndam Nicaise. (2015). High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin. Journal of Infectious Diseases, 211 (9), p. 1484-1488. ISSN 0022-1899.
Titre du document
High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin
Moussiliou A., Alao M. J., Denoeud Ndam Lise, Tahar Rachida, Ezimegnon S., Sagbo G., Amoussou A., Luty Adrian, Deloron Philippe, Tuikue Ndam Nicaise
Source
Journal of Infectious Diseases, 2015,
211 (9), p. 1484-1488 ISSN 0022-1899
Loss of endothelial protein C receptor (EPCR) occurs at the sites of Plasmodium falciparum-infected erythrocyte sequestration in patients with or who died from cerebral malaria. In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality. After adjustment for age, for treatment before admission, and for a known genetic factor, sEPCR level at admission was positively associated with cerebral malaria (P = .011) and with malaria-related mortality (P = .0003). Measuring sEPCR levels at admission could provide an early biological marker of the outcome of cerebral malaria.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]