@article{fdi:010064141,
  title = {{R}isk factors for {P}lasmodium falciparum gametocyte positivity in a longitudinal cohort},
  author = {{G}range, {L}. and {L}oucoubar, {C}. and {T}elle, {O}. and {T}all, {A}. and {F}aye, {J}. and {S}okhna, {C}heikh and {T}rape, {J}ean-{F}ran{\c{c}}ois and {S}akuntabhai, {A}. and {B}ureau, {J}. {F}. and {P}aul, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria transmission intensity is highly heterogeneous even at a very small scale. {I}mplementing targeted intervention in malaria transmission hotspots offers the potential to reduce the burden of disease both locally and in adjacent areas. {T}ransmission of malaria parasites from man to mosquito requires the production of gametocyte stage parasites. {C}luster analysis of a 19-year long cohort study for gametocyte carriage revealed spatially defined gametocyte hotspots that occurred during the time when chloroquine was the drug used for clinical case treatment. {I}n addition to known risk factors for gametocyte carriage, notably young age (<15 years old) and associated with a clinical episode, blood groups {B} and {O} increased risk compared to groups {A} and {AB}. {A} hotspot of clinical {P}. falciparum clinical episodes that overlapped the gametocyte hotspots was also identified. {G}ametocyte positivity was found to be increased in individuals who had been treated with chloroquine, as opposed to other drug treatment regimens, for a clinical {P}. falciparum episode up to 30 days previously. {I}t seems likely the hotspots were generated by a vicious circle of ineffective treatment of clinical cases and concomitant gametocyte production in a sub-population characterized by an increased prevalence of all the identified risk factors. {W}hile rapid access to treatment with an effective anti-malarial can reduce the duration of gametocyte carriage and onward parasite transmission, localised hotspots represent a challenge to malaria control and eventual eradication.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {10},
  numero = {4},
  pages = {e0123102 [13 p.]},
  ISSN = {1932-6203},
  year = {2015},
  DOI = {10.1371/journal.pone.0123102},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064141},
}