@article{fdi:010064055, title = {{N}ewinsights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences}, author = {{M}oureau, {G}r{\'e}gory and {C}ook, {S}. and {L}emey, {P}. and {N}ougairede, {A}. and {F}orrester, {N}. {L}. and {K}hasnatinov, {M}. and {C}harrel, {R}. {N}. and {F}irth, {A}. {E}. and {G}ould, {E}. {A}. and de {L}amballerie, {X}avier}, editor = {}, language = {{ENG}}, abstract = {{T}o generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with {C}ulex spp. mosquitoes. {W}e analyze these data, in conjunction with a comprehensive collection of flavivirus genomes, to characterize flavivirus evolutionary and biogeographic history in unprecedented detail and breadth. {B}ased on the presumed introduction of yellow fever virus into the {A}mericas via the transatlantic slave trade, we extrapolated a timescale for a relevant subset of flaviviruses whose evolutionary history, shows that different {C}ulex-spp. associated flaviviruses have been introduced from the {O}ld {W}orld to the {N}ew {W}orld on at least five separate occasions, with 2 different sets of factors likely to have contributed to the dispersal of the different viruses. {W}e also discuss the significance of programmed ribosomal frameshifting in a central region of the polyprotein open reading frame in some mosquito-associated flaviviruses.}, keywords = {}, booktitle = {}, journal = {{P}los {O}ne}, volume = {10}, numero = {2}, pages = {e0117849 [30 p.]}, ISSN = {1932-6203}, year = {2015}, DOI = {10.1371/journal.pone.0117849}, URL = {https://www.documentation.ird.fr/hor/fdi:010064055}, }