@article{fdi:010064050,
  title = {{T}herapeutic switching : from antidermatophytic essential oils to new leishmanicidal products},
  author = {{H}ou{\¨e}l, {E}. and {G}onzalez, {G}. and {B}essi{\`e}re, {J}. {M}. and {O}donne, {G}. and {E}parvier, {V}. and {D}eharo, {E}ric and {S}tien, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study examined whether the antidermatophytic activity of essential oils ({EO}s) can be used as an indicator for the discovery of active natural products against {L}eishmania amazonensis. {T}he aerial parts of seven plants were hydro-distilled. {U}sing broth microdilution techniques, the obtained {EO}s were tested against three strains of dermatophytes ({T}richophyton mentagrophytes, {M}icrosporum gypseum and {M}icrosporum canis). {T}o compare the {EO}s antifungal and antiparasitic effects, the {EO}s activities against axenic amastigotes of {L}. amazonensis were concurrently evaluated. {F}or the most promising {EO}s, their antileishmanial activities against parasites infecting peritoneal macrophages of {BALB}/c mice were measured. {T}he most interesting antifungal candidates were the {EO}s from {C}ymbopogon citratus, {O}tacanthus azureus and {P}rotium heptaphyllum, whereas {O}. azureus, {P}iper hispidum and {P}. heptaphyllum {EO}s exhibited the lowest 50% inhibitory concentration ({IC}50) values against axenic amastigotes, thus revealing a certain correspondence between both activities. {T}he {P}. hispidum {EO} was identified as the most promising product in the results from the infected macrophages model ({IC}50 : 4.7 mu g/m{L}, safety index: 8). {T}he most abundant compounds found in this {EO} were sesquiterpenes, notably curzerene and furanodiene. {E}ventually, the evaluation of the antidermatophytic activity of {EO}s appears to be an efficient method for identifying new potential drugs for the treatment of {L}. amazonensis.},
  keywords = {therapeutic switching ; antifungal agents ; antiparasitic agents ; {L}eishmania ; peritoneal macrophages ; sesquiterpenes ; {GUYANE} {FRANCAISE}},
  booktitle = {},
  journal = {{M}emorias do {I}nstituto {O}swaldo {C}ruz},
  volume = {110},
  numero = {1},
  pages = {106--113},
  ISSN = {0074-0276},
  year = {2015},
  DOI = {10.1590/0074-02760140332},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064050},
}