%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ayouba, Ahidjo
%A Njouom, R.
%A Chia, J. E.
%A Ahuka-Mundeke, S.
%A Kfutwah, A.
%A Ngole, E. M.
%A Nerrienet, E.
%A Delaporte, Eric
%A Peeters, Martine
%T Molecular characterization of a new mosaic Simian Immunodeficiency Virus in a naturally infected tantalus monkey (Chlorocebus tantalus) from Cameroon : a challenge to the virus-host co-evolution of SIVagm in African green monkeys
%D 2015
%L fdi:010064040
%G ENG
%J Infection Genetics and Evolution
%@ 1567-1348
%K SIV ; African green monkeys ; Phylogeny ; Cameroon
%K CAMEROUN
%M ISI:000350525400010
%P 65-73
%R 10.1016/j.meegid.2014.12.005
%U https://www.documentation.ird.fr/hor/fdi:010064040
%> https://www.documentation.ird.fr/intranet/publi/2015/04/010064040.pdf
%V 30
%W Horizon (IRD)
%X African green monkeys (AGMs) represent the most widely distributed non-human primates species in Africa. SIVagm naturally infects four of the 6 AGMs species at high prevalence in a species-specific manner. To date, only limited information is available on molecular characteristics of SIVagm infecting Chlorocebus tantalus. Here, we characterized the full-length genome of a virus infecting a naturally infected captive C. tantalus from Cameroon by amplifying and sequencing sub-genomic PCR fragments. The isolate (SIVagmTAN-CM545) is 9923 bp long and contained all canonical genes of a functional Sly. SIVagmTAN-CM545 showed a mosaic structure, with gag, pol, nef and accessory genes closely related to SIVagmSAB infecting Chlorocebus sabaeus monkeys from west Africa, and the env gene, closely related to SIVagmTAN infecting tantalus monkeys from Central Africa. Thus SIVagmTAN-CM545 is SIVagmSAB/SIVagmTAN recombinant. These unexpected findings suggest that the evolution of SIVagm is more complex than previously thought and warrant further studies.
%$ 052 ; 080 ; 020