@article{fdi:010064004,
  title = {{A}ccuracy of individual rapid tests for serodiagnosis of gambiense sleeping sickness in west {A}frica},
  author = {{J}amonneau, {V}incent and {C}amara, {O}. and {I}lboudo, {H}. and {P}eylhard, {M}. and {K}offi, {M}. and {S}akande, {H}. and {N}'{D}ri, {L}. and {S}anou, {D}. and {D}ama, {E}. and {C}amara, {M}. and {L}ejon, {V}eerle},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}ndividual rapid tests for serodiagnosis ({RDT}) of human {A}frican trypanosomiasis ({HAT}) are particularly suited for passive screening and surveillance. {H}owever, so far, no large scale evaluation of {RDT}s has been performed for diagnosis of {T}rypanosoma brucei gambiense {HAT} in {W}est {A}frica. {T}he objective of this study was to assess the diagnostic accuracy of 2 commercial {HAT}-{RDT}s on stored plasma samples from {W}est {A}frica. {M}ethodology/{P}rincipal findings {SD} {B}ioline {HAT} and {HAT} {S}ero-{K}-{S}et were performed on 722 plasma samples originating from {G}uinea and {C}ote d'{I}voire, including 231 parasitologically confirmed {HAT} patients, 257 healthy controls, and 234 unconfirmed individuals whose blood tested antibody positive in the card agglutination test but negative by parasitological tests. {I}mmune trypanolysis was performed as a reference test for trypanosome specific antibody presence. {S}ensitivities in {HAT} patients were respectively 99.6% for {SD} {B}ioline {HAT}, and 99.1% for {HAT} {S}ero-{K}-{S}et, specificities in healthy controls were respectively 87.9% and 88.3%. {C}onsidering combined positivity in both {RDT}s, increased the specificity significantly (p <= 0.0003) to 93.4%, while 98.7% sensitivity was maintained. {S}pecificities in controls were 98.7-99.6% for the combination of one or two {RDT}s with trypanolysis, maintaining a sensitivity of at least 98.1%. {C}onclusions/{S}ignificance {T}he observed specificity of the single {RDT}s was relatively low. {S}erial application of {SD} {B}ioline {HAT} and {HAT} {S}ero-{K}-{S}et might offer superior specificity compared to a single {RDT}, maintaining high sensitivity. {T}he combination of one or two {RDT}s with trypanolysis seems promising for {HAT} surveillance.},
  keywords = {{GUINEE} ; {COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {9},
  numero = {2},
  pages = {e0003480 [9 p.]},
  ISSN = {1935-2735},
  year = {2015},
  DOI = {10.1371/journal.pntd.0003480},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064004},
}