@article{fdi:010063775,
  title = {{I}nflammasome signaling pathways exert antiviral effect against {C}hikungunya virus in human dermal fibroblasts},
  author = {{E}kchariyawat, {P}. and {H}amel, {R}odolphe and {B}ernard, {E}. and {W}ichit, {S}. and {S}urasombatpattana, {P}. and {T}alignani, {L}. and {T}homas, {F}. and {C}houmet, {V}. and {Y}ssel, {H}. and {D}espr{\`e}s, {P}. and {B}riant, {L}. and {M}iss{\'e}, {D}oroth{\'e}e},
  editor = {},
  language = {{ENG}},
  abstract = {{A}rboviruses represent an emerging threat to human. {T}hey are transmitted to vertebrates by the bite of infected arthropods. {E}arly transmission to vertebrates is initiated by skin puncture and deposition of virus in this organ. {H}owever, events at the bite site remain largely unknown. {H}ere, we report that {C}hikungunya virus ({CHIKV}) and {W}est {N}ile virus ({WNV}), despite belonging to distinct viral families, elicit a common antiviral signature in primary human dermal fibroblasts, attesting for the up regulation of interferon signaling pathways and leading to an increased expression of {IFN}-β, interleukins and chemokines. {R}emarkably, {CHIKV} and {WNV} enhance {IL}-1β expression and induce maturation of caspase-1, indicating the capacity of these pathogens to elicit activation of the inflammasome program in resident skin cells. {CHIKV} and {WNV} also induce the expression of the inflammasome sensor {AIM}2 in dermal fibroblasts, whereas inhibition of caspase-1 and {AIM}2 with si{RNA} interferes with both {CHIKV}- and {WNV}-induced {IL}-1β production by these cells. {F}inally, inhibition of the inflammasome via caspase-1 silencing was found to enhance {CHIKV} replication in dermal fibroblasts. {T}ogether, these results indicate that the skin contributes to the pro-inflammatory and anti-viral microenvironment via the activation of the inflammasome in the early stages following infection with arboviruses.},
  keywords = {{ARBOVIROSE} ; {MOUSTIQUE} ; {INFECTION} ; {MECANISME} {DE} {DEFENSE} ; {IMMUNITE} ; {GENE} ; {ARN} ; {PROTEINE} ; {REPONSE} {IMMUNITAIRE} ; {EXPRESSION} {DES} {GENES} ; {PEAU}},
  booktitle = {},
  journal = {{I}nfection, {G}enetics and {E}volution},
  volume = {32},
  numero = {},
  pages = {401--408},
  ISSN = {1567-1348},
  year = {2015},
  DOI = {10.1016/j.meegid.2015.03.025},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063775},
}