@article{fdi:010063664, title = {{H}ighly evolvable malaria vectors : the genomes of 16 {A}nopheles mosquitoes}, author = {{N}eafsey, {D}. {E}. and {W}aterhouse, {R}. {M}. and {A}bai, {M}. {R}. and {A}ganezov, {S}. {S}. and {A}lekseyev, {M}. {A}. and {A}llen, {J}. {E}. and {A}mon, {J}. and {A}rca, {B}. and {A}rensburger, {P}. and {A}rtemov, {G}. and {A}ssour, {L}. {A}. and {B}asseri, {H}. and {B}erlin, {A}. and {B}irren, {B}. {W}. and {B}landin, {S}. {A}. and {B}rockman, {A}. {I}. and {B}urkot, {T}. {R}. and {B}urt, {A}. and {C}han, {C}. {S}. and {C}hauve, {C}. and {C}hiu, {J}. {C}. and {C}hristensen, {M}. and {C}ostantini, {C}arlo and {D}avidson, {V}. {L}. {M}. and {D}eligianni, {E}. and {D}ottorini, {T}. and {D}ritsou, {V}. and {G}abriel, {S}. {B}. and {G}uelbeogo, {W}. {M}. and {H}all, {A}. {B}. and {H}an, {M}. {V}. and {H}laing, {T}. and {H}ughes, {D}. {S}. {T}. and {J}enkins, {A}. {M}. and {J}iang, {X}. {F}. and {J}ungreis, {I}. and {K}akani, {E}. {G}. and {K}amali, {M}. and {K}emppainen, {P}. and {K}ennedy, {R}. {C}. and {K}irmitzoglou, {I}. {K}. and {K}oekemoer, {L}. {L}. and {L}aban, {N}. and {L}angridge, {N}. and {L}awniczak, {M}. {K}. {N}. and {L}irakis, {M}. and {L}obo, {N}. {F}. and {L}owy, {E}. and {M}ac{C}allum, {R}. {M}. and {M}ao, {C}. {H}. and {M}aslen, {G}. and {M}bogo, {C}. and {M}c{C}arthy, {J}. and {M}ichel, {K}. and {M}itchell, {S}. {N}. and {M}oore, {W}. and {M}urphy, {K}. {A}. and {N}aumenko, {A}. {N}. and {N}olan, {T}. and {N}ovoa, {E}. {M}. and {O}'{L}oughlin, {S}. and {O}ringanje, {C}. and {O}shaghi, {M}. {A}. and {P}akpour, {N}. and {P}apathanos, {P}. {A}. and {P}eery, {A}. {N}. and {P}ovelones, {M}. and {P}rakash, {A}. and {P}rice, {D}. {P}. and {R}ajaraman, {A}. and {R}eimer, {L}. {J}. and {R}inker, {D}. {C}. and {R}okas, {A}. and {R}ussell, {T}. {L}. and {S}agnon, {N}. and {S}harakhova, {M}. {V}. and {S}hea, {T}. and {S}imao, {F}. {A}. and {S}imard, {F}r{\'e}d{\'e}ric and {S}lotman, {M}. {A}. and {S}omboon, {P}. and {S}tegniy, {V}. and {S}truchiner, {C}. {J}. and {T}homas, {G}. {W}. {C}. and {T}ojo, {M}. and {T}opalis, {P}. and {T}ubio, {J}. {M}. {C}. and {U}nger, {M}. {F}. and {V}ontas, {J}. and {W}alton, {C}. and {W}ilding, {C}. {S}. and {W}illis, {J}. {H}. and {W}u, {Y}. {C}. and {Y}an, {G}. {Y}. and {Z}dobnov, {E}. {M}. and {Z}hou, {X}. {F}. and {C}atteruccia, {F}. and {C}hristophides, {G}. {K}. and {C}ollins, {F}. {H}. and {C}ornman, {R}. {S}. and {C}risanti, {A}. and {D}onnelly, {M}. {J}. and {E}mrich, {S}. {J}. and {F}ontaine, {M}. {C}. and {G}elbart, {W}. and {H}ahn, {M}. {W}. and {H}ansen, {I}. {A}. and {H}owell, {P}. {I}. and {K}afatos, {F}. {C}. and {K}ellis, {M}. and {L}awson, {D}. and {L}ouis, {C}. and {L}uckhart, {S}. and {M}uskavitch, {M}. {A}. {T}. and {R}ibeiro, {J}. {M}. and {R}iehle, {M}. {A}. and {S}harakhov, {I}. {V}. and {T}u, {Z}. {J}. and {Z}wiebel, {L}. {J}. and {B}esansky, {N}. {J}.}, editor = {}, language = {{ENG}}, abstract = {{V}ariation in vectorial capacity for human malaria among {A}nopheles mosquito species is determined by many factors, including behavior, immunity, and life history. {T}o investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning similar to 100 million years of evolution. {C}omparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the {X} chromosome, and more intron losses, relative to {D}rosophila. {S}ome determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. {T}his dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.}, keywords = {}, booktitle = {}, journal = {{S}cience}, volume = {347}, numero = {6217}, pages = {art. 1258522 [8 ]}, ISSN = {0036-8075}, year = {2015}, DOI = {10.1126/science.1258522}, URL = {https://www.documentation.ird.fr/hor/fdi:010063664}, }