@article{fdi:010063628,
  title = {{F}irst report of a family outbreak of {C}hagas disease in {F}rench {G}uiana and posttreatment follow-up},
  author = {{B}lanchet, {D}. and {B}reni{\`e}re, {S}imone {F}r{\'e}d{\'e}rique and {S}chijman, {A}. {G}. and {B}isio, {M}. and {S}imon, {S}. and {V}eron, {V}. and {M}ayence, {C}. and {D}emar-{P}ierre, {M}. and {D}jossou, {F}. and {A}znar, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he outbreak of acute {C}hagas disease due to oral transmission of the parasite is a well-known phenomenon mainly occurring in the {A}mazon. {S}uch an event is described here for the first time in {F}rench {G}uiana. {E}ight patients of the same family, presenting epidemiological and clinical histories compatible with recent {T}rypanosoma cruzi infection of {C}hagas disease due to the ingestion of palm {O}enocarpus bacaba juice were, rather late after the putative date of infection, underwent four parasitological and two serological specific tests for confirmation of the diagnosis. {R}eal-time {PCR} results were positive for all the patients; strains were isolated by hemoculture from four patients, {PCR} identification of {T}c{I} {DTU} was made for six patients, while parasites were not detected in any of the patients by direct microscopic examination. {T}he results of two serologic tests were positive. {A}ll patients were treated with benznidazole, and two patients were additionally given nifurtimox. {A} 6-year follow-up was possible for six patients. {R}eal-time {PCR} was negative for these patients after 1 year, while the antibody rates decreased slowly and serology results were negative only after several years (1-5 years). {O}ur findings confirm the occurrence of an outbreak of {C}hagas infection in members of the same family, with the oral mode of infection being the most likely hypothesis to explain this group of cases. {O}ur results show the successful treatment of patients infected by {T}c{I} and the usefulness of real-time {PCR} for the emergency diagnosis of recent {C}hagas disease cases and in posttreatment follow-up.},
  keywords = {{C}hagas disease ; {T}rypanosoma cruzi ; {F}rench {G}uiana ; {O}ral transmission ; {P}olymerase chain reaction ; {G}enotyping ; {GUYANE} {FRANCAISE}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {28},
  numero = {},
  pages = {245--250},
  ISSN = {1567-1348},
  year = {2014},
  DOI = {10.1016/j.meegid.2014.10.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063628},
}