@article{fdi:010063219,
  title = {{T}opography and land cover of watersheds predicts the distribution of the environmental pathogen {M}ycobacterium ulcerans in aquatic insects},
  author = {{C}arolan, {K}evin and {G}architorena, {A}ndres and {G}arcia {P}ena, {G}abriel and {M}orris, {A}aron and {L}andier, {J}. and {F}ontanet, {A}. and {L}e {G}all, {P}hilippe and {T}exier, {G}. and {M}arsollier, {L}. and {G}ozlan, {R}odolphe and {E}yangoh, {S}. and {L}o {S}een, {D}. and {G}u{\'e}gan, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}n understanding of the factors driving the distribution of pathogens is useful in preventing disease. {O}ften we achieve this understanding at a local microhabitat scale; however the larger scale processes are often neglected. {T}his can result in misleading inferences about the distribution of the pathogen, inhibiting our ability to manage the disease. {O}ne such disease is {B}uruli ulcer, an emerging neglected tropical disease afflicting many thousands in {A}frica, caused by the environmental pathogen {M}ycobacterium ulcerans. {H}erein, we aim to describe the larger scale landscape process describing the distribution of {M}. ulcerans. {M}ethodology: {F}ollowing extensive sampling of the community of aquatic macroinvertebrates in {C}ameroon, we select the 5 dominant insect {O}rders, and conduct an ecological niche model to describe how the distribution of {M}. ulcerans positive insects changes according to land cover and topography. {W}e then explore the generalizability of the results by testing them against an independent dataset collected in a second endemic region, {F}rench {G}uiana. {P}rincipal {F}indings: {W}e find that the distribution of the bacterium in {C}ameroon is accurately described by the land cover and topography of the watershed, that there are notable seasonal differences in distribution, and that the {C}ameroon model does not predict the distribution of {M}. ulcerans in {F}rench {G}uiana. {C}onclusions/{S}ignificance: {F}uture studies of {M}. ulcerans would benefit from consideration of local structure of the local stream network in future sampling, and further work is needed on the reasons for notable differences in the distribution of this species from one region to another. {T}his work represents a first step in the identification of large-scale environmental drivers of this species, for the purposes of disease risk mapping.},
  keywords = {{BACTERIOSE} ; {VECTEUR} ; {INSECTE} {AQUATIQUE} ; {AGENT} {PATHOGENE} ; {DISTRIBUTION} {SPATIALE} ; {TELEDETECTION} {SPATIALE} ; {MODELISATION} ; {COUVERT} {VEGETAL} ; {TOPOGRAPHIE} ; {BASSIN} {VERSANT} ; {VARIATION} {SAISONNIERE} ; {ULCERE} {DE} {BURULI} ; {CAMEROUN} ; {GUYANE} {FRANCAISE} ; {AKONOLINGA}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {8},
  numero = {11},
  pages = {art. e3298 [13  en ligne]},
  ISSN = {1935-2735},
  year = {2014},
  DOI = {10.1371/journal.pntd.0003298},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063219},
}