@article{fdi:010063147,
  title = {{B}eta-carboline alkaloids from {G}alianthe ramosa inhibit malate synthase from {P}aracoccidioides spp.},
  author = {de {F}reitas, {C}. {S}. and {K}ato, {L}. and de {O}liveira, {C}. {M}. {A}. and {Q}ueiroz, {L}. {H}. {K}. and {S}antana, {M}. {J}. and {S}chuquel, {I}. {T}. and {D}elprete, {P}iero and da {S}ilva, {R}. {A}. and {Q}uintino, {G}. {O}. and {N}eto, {B}. {R}. {D}. and {S}oares, {C}. {M}. {A}. and {P}ereira, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}s part of our continuing chemical and biological analyses of {R}ubiaceae species from {C}errado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from {G}alianthe ramosa. {A}lkaloid 2 inhibited malate synthase from the pathogenic fungus {P}aracoccidioides spp. {T}his enzyme is considered an important molecular target because it is not found in humans. {M}olecular docking simulations were used to describe the interactions between the alkaloids and malate synthase.},
  keywords = {{G}alianthe ramosa ; {R}ubiaceae ; indole alkaloids ; malate synthase ; {P}aracoccidioides spp. ; {BRESIL}},
  booktitle = {},
  journal = {{P}lanta {M}edica},
  volume = {80},
  numero = {18},
  pages = {1746--1752},
  ISSN = {0032-0943},
  year = {2014},
  DOI = {10.1055/s-0034-1383305},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063147},
}