de Freitas C. S., Kato L., de Oliveira C. M. A., Queiroz L. H. K., Santana M. J., Schuquel I. T., Delprete Piero, da Silva R. A., Quintino G. O., Neto B. R. D., Soares C. M. A., Pereira M. (2014). Beta-carboline alkaloids from Galianthe ramosa inhibit malate synthase from Paracoccidioides spp.. Planta Medica, 80 (18), p. 1746-1752. ISSN 0032-0943.
Titre du document
Beta-carboline alkaloids from Galianthe ramosa inhibit malate synthase from Paracoccidioides spp.
de Freitas C. S., Kato L., de Oliveira C. M. A., Queiroz L. H. K., Santana M. J., Schuquel I. T., Delprete Piero, da Silva R. A., Quintino G. O., Neto B. R. D., Soares C. M. A., Pereira M.
Source
Planta Medica, 2014,
80 (18), p. 1746-1752 ISSN 0032-0943
As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important molecular target because it is not found in humans. Molecular docking simulations were used to describe the interactions between the alkaloids and malate synthase.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Sciences du monde végétal [076]
