@article{fdi:010063104,
  title = {{A} heavy legacy : offspring of malaria- infected mosquitoes show reduced disease resistance},
  author = {{V}antaux, {A}m{\'e}lie and {D}abire, {K}. {R}. and {C}ohuet, {A}nna and {L}ef{\`e}vre, {T}hierry},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}rans-generational effects of immune stimulation may have either adaptive (trans-generational immune priming) or non-adaptive (fitness costs) effects on offspring ability to fight pathogens. {M}ethods: {A}nopheles coluzzii and its natural malaria parasite {P}lasmodium falciparum were used to test how maternal parasite infection affected offspring resistance to the same parasite species. {R}esults: {D}aughters of exposed mothers had similar qualitative resistance, as measured by their ability to prevent infection, relative to those of control mothers. {H}owever, maternal disease exposure altered offspring quantitative resistance, measured as the ability to limit parasite development, with mosquitoes of infected mothers suffering slightly increased parasite intensity compared to controls. {I}n addition, quantitative resistance was minimal in offspring of highly infected mothers, and in offspring issued from eggs produced during the early infection phase. {C}onclusions: {P}lasmodium falciparum infection in {A}n. coluzzii can have trans-generational costs, lowering quantitative resistance in offspring of infected mothers. {M}alaria-exposed mosquitoes might heavily invest in immune defences and thereby produce lower quality offspring that are poorly resistant.},
  keywords = {{A}nopheles coluzzii ; {A}nopheles gambiae {M} form ; {P}lasmodium falciparum ; {M}aternal effects ; {M}alaria ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {13},
  numero = {},
  pages = {art. 442 [7 p.]},
  ISSN = {1475-2875},
  year = {2014},
  DOI = {10.1186/1475-2875-13-442},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063104},
}