@article{fdi:010062833,
  title = {{C}ytoadherence phenotype of {P}lasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria},
  author = {{A}lmelli, {T}. and {T}uikue {N}dam, {N}icaise and {E}zimegnon, {S}. and {A}lao, {M}.{J}. and {A}houansou, {C}. and {S}agbo, {G}. and {A}moussou, {A}. and {D}eloron, {P}hilippe and {T}ahar, {R}achida},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {C}ytoadherence of {P}lasmodium falciparum-infected erythrocytes ({IE}s) in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral malaria ({CM}). {T}his biological process is thought to be mediated by {P}. falciparum erythrocyte membrane protein-1 ({P}f{EMP}-1) and human receptors such as {CD}36 and {ICAM}-1. {T}he relationship between the expression of {P}f{EMP}-1 variants and cytoadherence phenotype in the pathology of malaria is not well established. {M}ethods: {C}ytoadherence phenotypes of {IE}s to {CD}36, {ICAM}-1, {CSPG} and the transcription patterns of {A}, {B}, var2csa, var3, var gene groups and domain cassettes {DC}8 and {DC}13 were assessed in parasites from children with {CM} and uncomplicated malaria ({UM}) to determine if cytoadherence is related to a specific transcription profile of pfemp-1 variants. {R}esults: {P}arasites from {CM} patients bind significantly more to {CD}36 than those from {UM} patients, but no difference was observed in their binding ability to {ICAM}-1 and {CSPG}. {CM} isolates highly transcribed groups {A}, {B}, var2csa, var3, {DC}8 and {DC}13 compared to {UM} parasites. {T}he high transcription levels of var genes belonging to group {B} positively correlated with increased binding level to {CD}36. {C}onclusion: {CM} isolates bind significantly more to {CD}36 than to {ICAM}-1, which was correlated with high transcription level of group {B} var genes, supporting their implication in malaria pathogenesis.},
  keywords = {{PALUDISME} ; {ENFANT} ; {PARASITE} ; {MICROORGANISME} ; {PHENOTYPE} ; {CYTOADHERENCE} ; {ANALYSE} {GENETIQUE} ; {TECHNIQUE} {RT} {PCR} ; {BENIN} ; {COTONOU}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {13},
  numero = {1},
  pages = {art. 333 [9  en ligne]},
  ISSN = {1475-2875},
  year = {2014},
  DOI = {10.1186/1475-2875-13-333},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062833},
}