@article{fdi:010062831,
  title = {{T}he effects of dietary arachidonic acid on bone in flatfish larvae : the last but not the least of the essential fatty acids},
  author = {{B}oglino, {A}. and {D}arias, {M}aria {J}ose and {A}ndree, {K}.{B}. and {E}stevez, {A}. and {G}isbert, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}latfish can provide a reliable model to study developmental disorders in bone tissues occurring during morphogenesis in response to nutritional imbalances. {T}o date, most studies dealing with the effect of dietary essential fatty acids ({EFA}) on skeletogenesis in fish have focused their investigation on the role of docohexanoic (22:6n−3, {DHA}) and eicosapentaenoic (20:5n–3, {EPA}) acids, but only a few have focused on investigating the effects of arachidonic acid (20:4n–6, {ARA}) on bone during fish larval development. {B}one development and composition at larval stage have been demonstrated to be highly sensitive to dietary levels of {EFA}, in particular the {EPA} and {ARA} acids, both precursors for highly bioactive eicosanoids presenting opposite effects on bone metabolism. {S}ince fish are not able to synthesize {EFA}, they need to obtain them from the diet. {H}owever, dietary imbalances in {EPA} and {ARA} in flatfish larvae may disrupt bone formation and osteoblast differentiation in skeletal tissues, leading to the incidence of skeletal deformities, reduced mineralization and problems of bone remodelling in the cranial region associated with impaired eye migration. {T}hese anomalies in skeletal structures are one of the most important factors that affect flatfish larval quality and hamper their production. {T}hus, we have reviewed the current state of knowledge about the effects of dietary {ARA} contents on skeletogenesis in {S}enegalese sole ({S}olea senegalensis), one of the main flatfish species cultured in {E}urope. {T}heir larval quality still suffers for a high incidence of skeletal anomalies induced by dietary imbalances during metamorphosis.},
  keywords = {{AQUACULTURE} ; {POISSON} {MARIN} ; {LARVE} ; {ALIMENTATION} {ANIMALE} ; {ACIDE} {GRAS} ; {ACIDE} {ARACHIDONIQUE} ; {DEVELOPPEMENT} {BIOLOGIQUE} ; {MORPHOGENESE} ; {SQUELETTE} {VERTEBRE} ; {OS} ; {SOLE} ; {EUROPE}},
  booktitle = {{I}nterdisciplinary {A}pproaches in {F}ish {S}keletal {B}iology ({IAFSB})},
  journal = {{J}ournal of {A}pplied {I}chthyology},
  volume = {30},
  numero = {4},
  pages = {643--651},
  ISSN = {0175-8659},
  year = {2014},
  DOI = {10.1111/jai.12511},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062831},
}