Alout H., Yameogo B., Djogbénou L. S., Chandre Fabrice, Dabiré R. K., Corbel Vincent, Cohuet Anna. (2014). Interplay between Plasmodium infection and resistance to insecticides in vector mosquitoes. Journal of Infectious Diseases, 210 (9), p. 1464-1470. ISSN 0022-1899.
Titre du document
Interplay between Plasmodium infection and resistance to insecticides in vector mosquitoes
Alout H., Yameogo B., Djogbénou L. S., Chandre Fabrice, Dabiré R. K., Corbel Vincent, Cohuet Anna
Source
Journal of Infectious Diseases, 2014,
210 (9), p. 1464-1470 ISSN 0022-1899
Despite its epidemiological importance, the impact of insecticide resistance on vector-parasite interactions and malaria transmission is poorly understood. Here, we explored the impact of Plasmodium infection on the level of insecticide resistance to dichlorodiphenyltrichloroethane (DDT) in field-caught Anopheles gambiae sensu stricto homozygous for the kdr mutation. Results showed that kdr homozygous mosquitoes that fed on infectious blood were more susceptible to DDT than mosquitoes that fed on noninfectious blood during both ookinete development (day 1 after the blood meal) and oocyst maturation (day 7 after the blood meal) but not during sporozoite invasion of the salivary glands. Plasmodium falciparum infection seemed to impose a fitness cost on mosquitoes by reducing the ability of kdr homozygous A. gambiae sensu stricto to survive exposure to DDT. These results suggest an interaction between Plasmodium infection and the insecticide susceptibility of mosquitoes carrying insecticide-resistant alleles. We discuss this finding in relation to vector control efficacy.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
