@article{fdi:010062687,
  title = {{HIV}-1 {DNA} concentrations and evolution among {A}frican {HIV}-1-infected children under antiretroviral treatment ({ANRS} 1244/1278)},
  author = {{B}oull{\'e}, {C}. and {R}ouet, {F}. and {F}assinou, {P}. and {M}sellati, {P}hilippe and {B}eaudrap, {P}ierre de and {C}haix, {M}. {L}. and {R}ouzioux, {C}. and {A}vettand-{F}enoel, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he objectives of this study were to describe the pretreatment {HIV}-1 {DNA} concentrations in children infected with {HIV} and to evaluate the impact of antiretroviral therapy ({ART}) on {HIV}-{DNA} concentrations. {T}his was a retrospective analysis of all children followed up in the '{P}rogramme {E}nfant {Y}opougon' cohort, {A}bidjan, {C}{\^o}te d'{I}voire, from 2000 to 2004, who had cryopreserved peripheral blood mononuclear cells ({PBMC}s) and plasma samples. {HIV}-{DNA} was measured using a real-time {PCR} assay. {M}ixed-model analysis was used to analyse the factors associated with change in {HIV}-{DNA} concentration. {T}he study included 121 children infected with {HIV}-1. {T}he median age at inclusion was 6 years ({IQR}: 3.5-9) and children were at an advanced stage of {HIV} disease (46.6% and 20.3% presenting {CDC} stage {B} and {CDC} stage {C}, respectively). {A}t baseline, the median {HIV}-{DNA} concentration was 3.4 log(10) copies/10(6) {PBMC}s ({IQR}: 3.1-3.6). {F}ifty-four children were initiated on {ART} during follow-up. {A}fter 24 months of {ART}, {HIV}-{DNA} load decreased by 0.32 ({IQR}: 0.08-0.57) log(10) copies/10(6) {PBMC}s. {T}he only factor associated with the {HIV}-{DNA} decrease was a concomitant low {HIV}-{RNA} viral load result. {C}hildren with efficient {ART} had a 0.51 log(10) copies ({IQR}: 0.40-0.86) {HIV}-{DNA} decrease per million {PBMC}s. {HIV}-{DNA} concentrations decreased following {ART} initiation in a large {A}frican paediatric cohort. {T}his decline was exclusively associated with the decrease in ongoing replication level achieved. {O}ur study points out that a strong adherence is needed for {ART} to be efficient on the viral reservoirs, and further reinforces that adherence support is also essential to diminish the reservoir.},
  keywords = {{HIV}-{DNA} ; {A}frica ; cohort study ; {COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{J}ournal of {A}ntimicrobial {C}hemotherapy},
  volume = {69},
  numero = {11},
  pages = {3047--3050},
  ISSN = {0305-7453},
  year = {2014},
  DOI = {10.1093/jac/dku274},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062687},
}