Publications des scientifiques de l'IRD

Boullé C., Rouet F., Fassinou P., Msellati Philippe, Beaudrap Pierre de, Chaix M. L., Rouzioux C., Avettand-Fenoel R. (2014). HIV-1 DNA concentrations and evolution among African HIV-1-infected children under antiretroviral treatment (ANRS 1244/1278). Journal of Antimicrobial Chemotherapy, 69 (11), p. 3047-3050. ISSN 0305-7453.

Titre du document
HIV-1 DNA concentrations and evolution among African HIV-1-infected children under antiretroviral treatment (ANRS 1244/1278)
Année de publication
2014
Type de document
Article référencé dans le Web of Science WOS:000344605500027
Auteurs
Boullé C., Rouet F., Fassinou P., Msellati Philippe, Beaudrap Pierre de, Chaix M. L., Rouzioux C., Avettand-Fenoel R.
Source
Journal of Antimicrobial Chemotherapy, 2014, 69 (11), p. 3047-3050 ISSN 0305-7453
The objectives of this study were to describe the pretreatment HIV-1 DNA concentrations in children infected with HIV and to evaluate the impact of antiretroviral therapy (ART) on HIV-DNA concentrations. This was a retrospective analysis of all children followed up in the 'Programme Enfant Yopougon' cohort, Abidjan, Côte d'Ivoire, from 2000 to 2004, who had cryopreserved peripheral blood mononuclear cells (PBMCs) and plasma samples. HIV-DNA was measured using a real-time PCR assay. Mixed-model analysis was used to analyse the factors associated with change in HIV-DNA concentration. The study included 121 children infected with HIV-1. The median age at inclusion was 6 years (IQR: 3.5-9) and children were at an advanced stage of HIV disease (46.6% and 20.3% presenting CDC stage B and CDC stage C, respectively). At baseline, the median HIV-DNA concentration was 3.4 log(10) copies/10(6) PBMCs (IQR: 3.1-3.6). Fifty-four children were initiated on ART during follow-up. After 24 months of ART, HIV-DNA load decreased by 0.32 (IQR: 0.08-0.57) log(10) copies/10(6) PBMCs. The only factor associated with the HIV-DNA decrease was a concomitant low HIV-RNA viral load result. Children with efficient ART had a 0.51 log(10) copies (IQR: 0.40-0.86) HIV-DNA decrease per million PBMCs. HIV-DNA concentrations decreased following ART initiation in a large African paediatric cohort. This decline was exclusively associated with the decrease in ongoing replication level achieved. Our study points out that a strong adherence is needed for ART to be efficient on the viral reservoirs, and further reinforces that adherence support is also essential to diminish the reservoir.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
COTE D'IVOIRE
Localisation
Fonds IRD [F B010062687]
Identifiant IRD
fdi:010062687
Contact