@article{fdi:010062639,
  title = {{L}ong-term persistence of {C}hikungunya virus neutralizing antibodies in human populations of {N}orth {E}astern {T}hailand},
  author = {{N}itatpattana, {N}. and {K}anjanopas, {K}. and {Y}oksan, {S}. and {S}atimai, {W}. and {V}ongba, {N}. and {L}angdatsuwan, {S}. and {N}akgoi, {K}. and {R}atchakum, {S}. and {W}auquier, {N}. and {S}ouris, {M}arc and {A}uewarakul, {P}. and {G}onzalez, {J}ean-{P}aul},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {C}hikungunya virus ({CHIKV}) outbreak recurrences in {T}hailand are unpredictable and separated by unexplained and often long silent epidemiological periods that can last for several years. {T}hese silent periods could be explained in part by the fact that infection with one {CHIKV} strain confers lasting natural immunity, even against other {CHIKV} strains. {I}n this study we evaluated the persistence of {CHIKV}-specific neutralizing antibodies in the population of {C}humpae {D}istrict, {K}hon {K}aen {P}rovince, nineteen years after a {CHIKV} outbreak occurred in the same area in 1991. {F}indings: {O}verall 39% (44/111) of 111 former patients had neutralizing antibodies reacting against {CHIKV} {ECSA} strain. {C}onsistently high titers of neutralizing antibodies were found in 75% (33/44) of all positively-reacting sera, 70% of which (23/33) were collected from individuals amongst the >60 years old age group. {A}lthough the prevalence found in {P}ong {H}aeng village (70%) was significantly higher than the prevalence detected in the {N}ong {T}hum village (14%), control study villages without known previous {C}hikungunya epidemics had a high {C}hikungunya neutralizing antibody prevalence (65%). {C}onclusions: {M}ore than one-third of the pre-exposed population had persisting natural immunity that was more likely boosted by recent and repetitive exposure to the emerging {ECSA} {CHIKV} in {T}hailand. {A}lso, {C}hikungunya virus appears to largely circulate in the country with a great variability appears between villages or area probably associated with the vector abundance and efficiency. {A}ltogether these results show a potential for a lifelong immunity against {CHIKV}. {G}iven the rapid spread of the highly pathogenic {ECSA} strain in {S}outhern {T}hailand, the development of {CHIK} vaccine is strongly recommended.},
  keywords = {{C}hikungunya virus ; {C}ross-neutralization ; {T}hailand ; {THAILANDE}},
  booktitle = {},
  journal = {{V}irology {J}ournal},
  volume = {11},
  numero = {},
  pages = {art. 183 [5 ]},
  ISSN = {1743-422{X}},
  year = {2014},
  DOI = {10.1186/1743-422x-11-183},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062639},
}