Publications des scientifiques de l'IRD

Boselli L., Ader I., Carraz Maëlle, Hemmert C., Cuvillier O., Gornitzka H. (2014). Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands. European Journal of Medicinal Chemistry, 85, p. 87-94. ISSN 0223-5234.

Titre du document
Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands
Année de publication
2014
Type de document
Article référencé dans le Web of Science WOS:000342859700008
Auteurs
Boselli L., Ader I., Carraz Maëlle, Hemmert C., Cuvillier O., Gornitzka H.
Source
European Journal of Medicinal Chemistry, 2014, 85, p. 87-94 ISSN 0223-5234
New gold(I) complexes containing two 1-[2-(diethylamino)ethyl]imidazolydene ligands have been synthesized and characterized. The X-ray structures of two key compounds are presented. All complexes have been tested for their antiproliferative activities in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells. The most active complex demonstrated a potent selectivity for cancer cells.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Santé : généralités [050]
Localisation
Fonds IRD [F B010062607]
Identifiant IRD
fdi:010062607
Contact