Otto T. D., Rayner J. C., Bohme U., Pain A., Spottiswoode N., Sanders M., Quail M., Ollomo B., Renaud F., Thomas A. W., Prugnolle Franck, Conway D. J., Newbold C., Berriman M. (2014). Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. Nature Communications, 5, art. 4754 [9 p.]. ISSN 2041-1723.
Titre du document
Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
Année de publication
2014
Auteurs
Otto T. D., Rayner J. C., Bohme U., Pain A., Spottiswoode N., Sanders M., Quail M., Ollomo B., Renaud F., Thomas A. W., Prugnolle Franck, Conway D. J., Newbold C., Berriman M.
Source
Nature Communications, 2014,
5, art. 4754 [9 p.] ISSN 2041-1723
Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, and obtaining partial sequence data from a more distantly related chimpanzee parasite (P. gaboni). The close relationship between P. reichenowi and P. falciparum is emphasized by almost complete conservation of genomic synteny, but against this strikingly conserved background we observe major differences at loci involved in erythrocyte invasion. The organization of most virulence-associated multigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a smaller subset of rif and stevor genes whose products are expressed on the infected erythrocyte surface. Genome-wide analysis identifies other loci under recent positive selection, but a limited number of changes at the host-parasite interface may have mediated host switching.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
Description Géographique
AFRIQUE
Localisation
Fonds IRD [F B010062602]
Identifiant IRD
fdi:010062602
