@article{fdi:010062564,
  title = {{E}volving molecular epidemiological profile of human immunodeficiency virus 1 in the southwest border of {C}hina},
  author = {{C}hen, {Y}. {Y}. and {C}hen, {S}. and {K}ang, {J}. and {F}ang, {H}. and {D}ao, {H}. and {G}uo, {W}. {Z}. and {L}ai, {C}. {H}. and {L}ai, {M}. {Y}. and {F}an, {J}. {H}. and {F}u, {L}. {C}. and {A}ndrieu, {J}. {M}. and {L}u, {W}ei},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {W}e have previously reported in {X}ishuangbanna ({B}anna) {D}ai {A}utonomous {P}refecture, a well-developed tourist destination in the southwest border of {C}hina, that {HIV}-1 transmitted dominantly through heterosexual contact with less divergent genotypes and few drug resistant mutations [1]. {D}ue to the rapid increase of newly diagnosed {HIV}-1 cases per year in {B}anna in recent years, it's important to evaluate the evolution of {HIV}-1 molecular epidemiology for the better understanding of ongoing {HIV}-1 outbreak in this region. {M}ethodology/{P}rincipal {F}indings: {B}y sequencing of {HIV}-1 pol genes and phylogenetic analysis, we conducted a molecular epidemiologic study in 352 {HIV}-1-seropositive highly active antiretroviral treatment ({HAART})-naive individuals newly diagnosed at the {B}anna {C}enter for {D}isease {C}ontrol and {P}revention between 2009 and 2011. {O}f 283 samples (84.1% taken from heterosexually acquired adults, 10.6% from needle-sharing drug users, 2.8% from men who have sex with men, 0.4% from children born from {HIV}-1-infected mothers, and 2.1% remained unknown) with successful sequencing for pol gene, we identified 108 (38.2%) {HIV}-1 subtype {CRF}08_{BC}, 101 (35.7%) {CRF}01_{AE}, 49 (17.3%) {CRF}07_{BC}, 5 (1.8%) {C}/{CRF}57_{BC}, 3 (1.1%) {B}', 1 (0.4%) {B}/{CRF}51_01{B}, and 16 (5.7%) unique recombinants forms. {A}mong these infected individuals, 104 (36.7%) cases showed drug resistant or resistance-relevant mutations, and 4 of them conferring high-level resistance to 3{TC}/{FTC}, {EFV}/{NVP} or {NFV}. {P}hylogenetic analysis revealed 21 clusters (2-7 sequences) with only 21.2% (60/283) sequences involved. {C}onclusion/{S}ignificance: {I}n contrast to our previous findings, {CRF}08_{BC}, replaced {CRF}01_{AE}, became the dominant genotype of {HIV}-1 in {B}anna prefecture. {T}he viral strains with drug resistance mutations were detected frequently in newly diagnosed {HIV}-1-infected individuals in this region.},
  keywords = {{CHINE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {9},
  pages = {e107578},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0107578},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062564},
}