@article{fdi:010062552,
  title = {{D}ynamics in the cytoadherence phenotypes of {P}lasmodium falciparum infected erythrocytes isolated during pregnancy},
  author = {{D}oritchamou, {J}. and {S}ossou-{T}chatcha, {S}. and {C}ottrell, {G}illes and {M}oussiliou, {A}. and {H}oungbeme, {C}. {H}. and {M}assougbodji, {A}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{P}regnant women become susceptible to malaria infection despite their acquired immunity to this disease from childhood. {T}he placental sequestration of {P}lasmodium falciparum infected erythrocytes ({IE}) is the major feature of malaria during pregnancy, due to ability of these parasites to bind chondroitin sulfate {A} ({CSA}) in the placenta through the {VAR}2{CSA} protein that parasites express on the surface of {IE}. {W}e collected parasites at different times of pregnancy and investigated the adhesion pattern of freshly collected isolates on the three well described host receptors ({CSPG}, {CD}36 and {ICAM}-1). {V}ar genes transcription profile and {VAR}2{CSA} surface-expression were assessed in these isolates. {A}lthough adhesion of {IE} to {CD}36 and {ICAM}-1 was observed in some isolates, {CSA}-adhesion was the predominant binding feature in all isolates analyzed. {C}o-existence in the peripheral blood of several adhesion phenotypes in early pregnancy isolates was observed, a diversity that gradually tightens with gestational age in favour of the {CSA}-adhesion phenotype. {I}nfections occurring in primigravidae were often by parasites that adhered more to {CSA} than those from multigravidae. {D}ata from this study further emphasize the specificity of {CSA} adhesion and {VAR}2{CSA} expression by parasites responsible for pregnancy malaria, while drawing attention to the phenotypic complexity of infections occurring early in pregnancy as well as in multigravidae.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {6},
  pages = {e98577},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0098577},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062552},
}