@article{fdi:010062514, title = {{T}he coffee genome provides insight into the convergent evolution of caffeine biosynthesis}, author = {{D}enoeud, {F}. and {C}arretero-{P}aulet, {L}. and {D}ereeper, {A}lexis and {D}roc, {G}. and {G}uyot, {R}omain and {P}ietrella, {M}. and {Z}heng, {C}. {F}. and {A}lberti, {A}. and {A}nthony, {F}ran{\c{c}}ois and {A}prea, {G}. and {A}ury, {J}. {M}. and {B}ento, {P}. and {B}ernard, {M}. and {B}ocs, {S}. and {C}ampa, {C}laudine and {C}enci, {A}lberto and {C}ombes, {M}arie-{C}hristine and {C}rouzillat, {D}. and {D}a {S}ilva, {C}. and {D}addiego, {L}. and {D}e {B}ellis, {F}. and {D}ussert, {S}t{\'e}phane and {G}arsmeur, {O}. and {G}ayraud, {T}. and {G}uignon, {V}. and {J}ahn, {K}. and {J}amilloux, {V}. and {J}o{\¨e}t, {T}hierry and {L}abadie, {K}. and {L}an, {T}. {Y}. and {L}eclercq, {J}. and {L}epelley, {M}. and {L}eroy, {T}. and {L}i, {L}. {T}. and {L}ibrado, {P}. and {L}opez, {L}. and {M}unoz, {A}. and {N}oel, {B}. and {P}allavicini, {A}. and {P}errotta, {G}. and {P}oncet, {V}al{\'e}rie and {P}ot, {D}. and {P}riyono, and {R}igoreau, {M}. and {R}ouard, {M}. and {R}ozas, {J}. and {D}ubreuil {T}ranchant, {C}hristine and {V}an {B}uren, {R}. and {Z}hang, {Q}. and {A}ndrade, {A}. {C}. and {A}rgout, {X}. and {B}ertrand, {B}. and {K}ochko, {A}lexandre de and {G}raziosi, {G}. and {H}enry, {R}. {J}. and {J}ayarama, and {M}ing, {R}. and {N}agai, {C}. and {R}ounsley, {S}. and {S}ankoff, {D}. and {G}iuliano, {G}. and {A}lbert, {V}. {A}. and {W}incker, {P}. and {L}ashermes, {P}hilippe}, editor = {}, language = {{ENG}}, abstract = {{C}offee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. {W}e generated a high-quality draft genome of the species {C}offea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. {A}lthough it shows no sign of the whole-genome triplication identified in {S}olanaceae species such as tomato, the genome includes several species-specific gene family expansions, among them {N}-methyltransferases ({NMT}s) involved in caffeine production, defense-related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis. {C}omparative analyses of caffeine {NMT}s demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.}, keywords = {}, booktitle = {}, journal = {{S}cience}, volume = {345}, numero = {6201}, pages = {1181--1184}, ISSN = {0036-8075}, year = {2014}, DOI = {10.1126/science.1255274}, URL = {https://www.documentation.ird.fr/hor/fdi:010062514}, }