@article{fdi:010062507,
  title = {{I}n vitro and {I}n vivo activity of {B}enzo[c]phenanthridines against {L}eishmania amazonensis},
  author = {{C}astillo, {D}. and {S}auvain, {M}ichel and {R}ivaud, {M}. and {J}ullian, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{S}even benzo[c]phenanthridines, synthetic or isolated from {Z}anthoxylum rhoifolium root bark, were evaluated against {L}eishmania amazonensis axenic amastigotes. {F}ive of them were considered leishmanicidal, with {IC}50 values ranging from 0.03 to 0.54 mu {M}, and were evaluated on intramacrophagic amastigotes of {L}. amazonensis. {C}helerythrine displayed the best activity ({IC}50 = 0.5 mu {M}), which was in the same range as the reference compound amphotericin {B} ({IC}50 = 0.4 mu {M}). {I}n vivo studies with chelerythrine, avicine, and fagaridine on a model of mice cutaneous leishmaniasis resulted in the identification of fagaridine as the most active compound. {F}agaridine decreased the parasitic burden more than 50% at the 3rd and 6th weeks after the end of treatment.},
  keywords = {leishmaniasis ; {L}eishmania amazonensis ; in vitro ; in vivo ; leishmanicidal ; benzo[c]phenanthridines ; {Z}anthoxylum rhoifolium ; {R}utaceae ; {GUYANE} {FRANCAISE} ; {AMAZONIE}},
  booktitle = {},
  journal = {{P}lanta {M}edica},
  volume = {80},
  numero = {11},
  pages = {902--906},
  ISSN = {0032-0943},
  year = {2014},
  DOI = {10.1055/s-0034-1382826},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062507},
}