%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sadissou, I.
%A D'almeida, Tania
%A Cottrell, Gilles
%A Luty, Adrian
%A Krawice-Radanne, I.
%A Massougbodji, A.
%A Moreau, P.
%A Moutairou, K.
%A Garcia, André
%A Favier, B.
%A Rouas-Freiss, N.
%A Courtin, David
%T High plasma levels of HLA-G are associated with low birth weight and with an increased risk of malaria in infancy
%D 2014
%L fdi:010062493
%G ENG
%J Malaria Journal
%@ 1475-2875
%K Plasmodium falciparum ; Malaria ; HLA-G ; Susceptibility ; Low birth weight
%M ISI:000341033200001
%P art. 312 [8 ]
%R 10.1186/1475-2875-13-312
%U https://www.documentation.ird.fr/hor/fdi:010062493
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010062493.pdf
%V 13
%W Horizon (IRD)
%X Background: The immunosuppressive properties of HLA-G protein can create a tolerogenic environment that may allow Plasmodium falciparum to avoid host immune responses. There are known associations between high levels of circulating soluble HLA-G (sHLA-G) and either parasite or viral infections and it has been suggested that the induction of sHLA-G expression could be a mechanism via which infectious agents subvert host immune defence. The study presented here is the first to investigate the possible association between sHLA-G and malaria or malaria related risk factors in Benin. Methods: A parasitological and clinical follow-up of 165 mothers and their newborns from delivery through to one year of age was conducted in the Tori Bossito area of southern Benin. Plasma levels of sHLA-G were determined by ELISA in maternal peripheral and cord blood and again in infants' peripheral blood at 3, 6, 9 and 12 months of age. The associations between the levels of sHLA-G and malaria risk factors were investigated through multivariate mixed models. Results: Strong correlations were observed between the maternal and cord plasma concentrations of sHLA-G. In multivariate analyses, high cord plasma levels of sHLA-G were independently associated with (i) low birth weight and (ii) an increased risk of P. falciparum infection in infancy. Conclusion: These results show for the first time the possible involvement of sHLA-G in generating immune tolerance during pregnancy-associated malaria. Soluble HLA-G may represent a useful marker of susceptibility to malaria in infants and be associated with the higher susceptibility to infection observed for LBW children.
%$ 052 ; 050