@article{fdi:010062493,
  title = {{H}igh plasma levels of {HLA}-{G} are associated with low birth weight and with an increased risk of malaria in infancy},
  author = {{S}adissou, {I}. and {D}'almeida, {T}ania and {C}ottrell, {G}illes and {L}uty, {A}drian and {K}rawice-{R}adanne, {I}. and {M}assougbodji, {A}. and {M}oreau, {P}. and {M}outairou, {K}. and {G}arcia, {A}ndr{\'e} and {F}avier, {B}. and {R}ouas-{F}reiss, {N}. and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he immunosuppressive properties of {HLA}-{G} protein can create a tolerogenic environment that may allow {P}lasmodium falciparum to avoid host immune responses. {T}here are known associations between high levels of circulating soluble {HLA}-{G} (s{HLA}-{G}) and either parasite or viral infections and it has been suggested that the induction of s{HLA}-{G} expression could be a mechanism via which infectious agents subvert host immune defence. {T}he study presented here is the first to investigate the possible association between s{HLA}-{G} and malaria or malaria related risk factors in {B}enin. {M}ethods: {A} parasitological and clinical follow-up of 165 mothers and their newborns from delivery through to one year of age was conducted in the {T}ori {B}ossito area of southern {B}enin. {P}lasma levels of s{HLA}-{G} were determined by {ELISA} in maternal peripheral and cord blood and again in infants' peripheral blood at 3, 6, 9 and 12 months of age. {T}he associations between the levels of s{HLA}-{G} and malaria risk factors were investigated through multivariate mixed models. {R}esults: {S}trong correlations were observed between the maternal and cord plasma concentrations of s{HLA}-{G}. {I}n multivariate analyses, high cord plasma levels of s{HLA}-{G} were independently associated with (i) low birth weight and (ii) an increased risk of {P}. falciparum infection in infancy. {C}onclusion: {T}hese results show for the first time the possible involvement of s{HLA}-{G} in generating immune tolerance during pregnancy-associated malaria. {S}oluble {HLA}-{G} may represent a useful marker of susceptibility to malaria in infants and be associated with the higher susceptibility to infection observed for {LBW} children.},
  keywords = {{P}lasmodium falciparum ; {M}alaria ; {HLA}-{G} ; {S}usceptibility ; {L}ow birth weight},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {13},
  numero = {},
  pages = {art. 312 [8 ]},
  ISSN = {1475-2875},
  year = {2014},
  DOI = {10.1186/1475-2875-13-312},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062493},
}