@article{fdi:010062468,
  title = {{P}regnancy-associated malaria and malaria in infants : an old problem with present consequences},
  author = {{M}oya-{A}lvarez, {V}ioleta and {A}bellana, {R}. and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{A}lbeit pregnancy-associated malaria ({PAM}) poses a potential risk for over 125 million women each year, an accurate review assessing the impact on malaria in infants has yet to be conducted. {I}n addition to an effect on low birth weight ({LBW}) and prematurity, {PAM} determines foetal exposure to {P}lasmodium falciparum in utero and is correlated to congenital malaria and early development of clinical episodes during infancy. {T}his interaction plausibly results from an ongoing immune tolerance process to antigens in utero, however, a complete explanation of this immune process remains a question for further research, as does the precise role of protective maternal antibodies. {P}reventive interventions against {PAM} modify foetal exposure to {P}. falciparum in utero, and have thus an effect on perinatal malaria outcomes. {E}ffective intermittent preventive treatment in pregnancy ({IPT}p) diminishes placental malaria ({PM}) and its subsequent malaria-associated morbidity. {H}owever, emerging resistance to sulphadoxine-pyrimethamine ({SP}) is currently hindering the efficacy of {IPT}p regimes and the efficacy of alternative strategies, such as intermittent screening and treatment ({IST}), has not been accurately evaluated in different transmission settings. {D}ue to the increased risk of clinical malaria for offspring of malaria infected mothers, {PAM} preventive interventions should ideally start during the preconceptual period. {I}nnovative research examining the effect of {PAM} on the neurocognitive development of the infant, as well as examining the potential influence of {HLA}-{G} polymorphisms on malaria symptoms, is urged to contribute to a better understanding of {PAM} and infant health.},
  keywords = {{P}regnancy-associated malaria ; {I}mmune tolerance ; {I}ntermittent preventive ; treatment in pregnancy ; {P}arasitaemia ; {I}nfancy ; {S}ulphadoxine-pyrimethamine ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {13},
  numero = {},
  pages = {art. 271 [10 ]},
  ISSN = {1475-2875},
  year = {2014},
  DOI = {10.1186/1475-2875-13-271},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062468},
}