@article{fdi:010062438,
  title = {{S}alivary gland proteome analysis reveals modulation of anopheline unique proteins in insensitive acetylcholinesterase resistant {A}nopheles gambiae mosquitoes},
  author = {{C}orn{\'e}lie, {S}ylvie and {R}ossignol, {M}arie and {S}eveno, {M}. and {D}emettre, {E}. and {M}ouchet, {F}ran{\c{c}}ois and {D}j{\`e}gb{\'e}, {I}. and {M}arin, {P}. and {C}handre, {F}abrice and {C}orbel, {V}incent and {R}emou{\'e}, {F}ranck and {M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nsensitive acetylcholinesterase resistance due to a mutation in the acetylcholinesterase (ace) encoding ace-1 gene confers cross-resistance to organophosphate and carbamate insecticides in {A}nopheles gambiae populations from {C}entral and {W}est {A}frica. {T}his mutation is associated with a strong genetic cost revealed through alterations of some life history traits but little is known about the physiological and behavioural changes in insects bearing the ace-1 {R} allele. {C}omparative analysis of the salivary gland contents between {A}n. gambiae susceptible and ace-1 {R} resistant strains was carried out to charaterize factors that could be involved in modifications of blood meal process, trophic behaviour or pathogen interaction in the insecticide-resistant mosquitoes. {D}ifferential analysis of the salivary gland protein profiles revealed differences in abundance for several proteins, two of them showing major differences between the two strains. {T}hese two proteins identified as saglin and {TRIO} are salivary gland-1 related proteins, a family unique to anopheline mosquitoes, one of them playing a crucial role in salivary gland invasion by {P}lasmodium falciparum sporozoites. {D}ifferential expression of two other proteins previously identified in the {A}nopheles sialome was also observed. {T}he differentially regulated proteins are involved in pathogen invasion, blood feeding process, and protection against oxidation, relevant steps in the outcome of malaria infection. {F}urther functional studies and insect behaviour experiments would confirm the impact of the modification of the sialome composition on blood feeding and pathogen transmission abilities of the resistant mosquitoes. {T}he data supports the hypothesis of alterations linked to insecticide resistance in the biology of the primary vector of human malaria in {A}frica.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {8},
  pages = {art. e103816},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0103816},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062438},
}