@article{fdi:010062363,
  title = {{E}pidemiology of {L}eptospira transmitted by rodents in {S}outheast {A}sia},
  author = {{C}osson, {J}. {F}. and {P}icardeau, {M}. and {M}ielcarek, {M}. and {T}atard, {C}. and {C}haval, {Y}. and {S}uputtamongkol, {Y}. and {B}uchy, {P}. and {J}ittapalapong, {S}. and {H}erbreteau, {V}incent and {M}orand, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {L}eptospirosis is the most common bacterial zoonoses and has been identified as an important emerging global public health problem in {S}outheast {A}sia. {R}odents are important reservoirs for human leptospirosis, but epidemiological data is lacking. {M}ethodology/{P}rincipal {F}indings: {W}e sampled rodents living in different habitats from seven localities distributed across {S}outheast {A}sia ({T}hailand, {L}ao {PDR} and {C}ambodia), between 2009 to 2010. {H}uman isolates were also obtained from localities close to where rodents were sampled. {T}he prevalence of {L}eptospira infection was assessed by real-time {PCR} using {DNA} extracted from rodent kidneys, targeting the lip{L}32 gene. {S}equencing rrs and sec{Y} genes, and {M}ulti {L}ocus {V}ariable-number {T}andem {R}epeat ({VNTR}) analyses were performed on {DNA} extracted from rat kidneys for {L}eptospira isolates molecular typing. {F}our species were detected in rodents, {L}. borgpetersenii (56% of positive samples), {L}. interrogans (36%), {L}. kirschneri (3%) and {L}. weilli (2%), which were identical to human isolates. {M}ean prevalence in rodents was approximately 7%, and largely varied across localities and habitats, but not between rodent species. {T}he two most abundant {L}eptospira species displayed different habitat requirements: {L}. interrogans was linked to humid habitats (rice fields and forests) while {L}. borgpetersenii was abundant in both humid and dry habitats (non-floodable lands). {C}onclusion/{S}ignificance: {L}. interrogans and {L}. borgpetersenii species are widely distributed amongst rodent populations, and strain typing confirmed rodents as reservoirs for human leptospirosis. {D}ifferences in habitat requirements for {L}. interrogans and {L}. borgpetersenii supported differential transmission modes. {I}n {S}outheast {A}sia, human infection risk is not only restricted to activities taking place in wetlands and rice fields as is commonly accepted, but should also include tasks such as forestry work, as well as the hunting and preparation of rodents for consumption, which deserve more attention in future epidemiological studies.},
  keywords = {{THAILANDE} ; {LAOS} ; {CAMBODGE}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {8},
  numero = {6},
  pages = {e2902},
  ISSN = {1935-2735},
  year = {2014},
  DOI = {10.1371/journal.pntd.0002902},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062363},
}