@article{fdi:010062358,
  title = {{I}nsecticide resistance in disease vectors from {M}ayotte : an opportunity for integrated vector management},
  author = {{P}ocquet, {N}icolas and {D}arriet, {F}r{\'e}d{\'e}ric and {Z}umbo, {B}. and {M}ilesi, {P}. and {T}hiria, {J}. and {B}ernard, {V}. and {T}oty, {C}{\'e}line and {L}abbe, {P}. and {C}handre, {F}abrice},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}ayotte, a small island in the {I}ndian {O}cean, has been affected for many years by vector-borne diseases. {M}alaria, {B}ancroftian filariasis, dengue, chikungunya and {R}ift {V}alley fever have circulated or still circulate on the island. {T}hey are all transmitted by {C}ulicidae mosquitoes. {T}o limit the impact of these diseases on human health, vector control has been implemented for more than 60 years on {M}ayotte. {I}n this study, we assessed the resistance levels of four major vector species ({A}nopheles gambiae, {C}ulex pipiens quinquefasciatus, {A}edes aegypti and {A}edes albopictus) to two types of insecticides: i) the locally currently-used insecticides (organophosphates, pyrethroids) and ii) alternative molecules that are promising for vector control and come from different insecticide families (bacterial toxins or insect growth regulators). {W}hen some resistance was found to one of these insecticides, we characterized the mechanisms involved. {M}ethods: {L}arval and adult bioassays were used to evaluate the level of resistance. {W}hen resistance was found, we tested for the presence of metabolic resistance through detoxifying enzyme activity assays, or for target-site mutations through molecular identification of known resistance alleles. {R}esults: {R}esistance to currently-used insecticides varied greatly between the four vector species. {W}hile no resistance to any insecticides was found in the two {A}edes species, bioassays confirmed multiple resistance in {C}x. p. quinquefasciatus (temephos: similar to 20 fold and deltamethrin: only 10% mortality after 24 hours). {I}n {A}n. gambiae, resistance was scarce: only a moderate resistance to temephos was found (similar to 5 fold). {T}his resistance appears to be due only to carboxyl-esterase overexpression and not to target modification. {F}inally, and comfortingly, none of the four species showed resistance to any of the new insecticides. {C}onclusions: {T}he low resistance observed in {M}ayotte's main disease vectors is particularly interesting, because it leaves a range of tools useable by vector control services. {T}ogether with the relative isolation of the island (thus limited immigration of mosquitoes), it provides us with a unique place to implement an integrated vector management plan, including all the good practices learned from previous experiences.},
  keywords = {{I}nsecticide resistance ; {M}osquito control ; {R}esistance management ; {I}ntegrated vector management ; {MAYOTTE} ; {COMORES}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {7},
  numero = {},
  pages = {art. 299},
  ISSN = {1756-3305},
  year = {2014},
  DOI = {10.1186/1756-3305-7-299},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062358},
}