@article{fdi:010062320,
  title = {{L}imited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the {TAS}2{R}16 bitter taste receptor gene in {A}frica},
  author = {{C}ampbell, {M}. {C}. and {R}anciaro, {A}. and {Z}inshteyn, {D}. and {R}awlings-{G}oss, {R}. and {H}irbo, {J}. and {T}hompson, {S}. and {W}oldemeskel, {D}. and {F}roment, {A}lain and {O}mar, {S}. {A}. and {B}odo, {J}. {M}. and {N}yambo, {T}. and {B}elay, {G}. and {D}rayna, {D}. and {B}reslin, {P}. {A}. {S}. and {T}ishkoff, {S}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}itter taste perception, mediated by receptors encoded by the {TAS}2{R} loci, has important roles in human health and nutrition. {P}rior studies have demonstrated that nonsynonymous variation at site 516 in the coding exon of {TAS}2{R}16, a bitter taste receptor gene on chromosome 7, has been subject to positive selection and is strongly correlated with differences in sensitivity to salicin, a bitter anti-inflammatory compound, in human populations. {H}owever, a recent study suggested that the derived {G}-allele at rs702424 in the {TAS}2{R}16 promoter has also been the target of recent selection and may have an additional effect on the levels of salicin bitter taste perception. {H}ere, we examined alleles at rs702424 for signatures of selection using {E}xtended {H}aplotype {H}omozygosity ({EHH}) and {F}-{ST} statistics in diverse populations from {W}est {C}entral, {C}entral and {E}ast {A}frica. {W}e also performed a genotype-phenotype analysis of salicin sensitivity in a subset of 135 individuals from {E}ast {A}frica. {B}ased on our data, we did not find evidence for positive selection at rs702424 in {A}frican populations, suggesting that nucleotide position 516 is likely the site under selection at {TAS}2{R}16. {M}oreover, we did not detect a significant association between rs702424 alleles and salicin bitter taste recognition, implying that this site does not contribute to salicin phenotypic variance. {O}verall, this study of {A}frican diversity provides further information regarding the genetic architecture and evolutionary history of a biologically-relevant trait in humans.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {{J}ournal of {H}uman {G}enetics},
  volume = {59},
  numero = {6},
  pages = {349--352},
  ISSN = {1434-5161},
  year = {2014},
  DOI = {10.1038/jhg.2014.29},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062320},
}