Campbell M. C., Ranciaro A., Zinshteyn D., Rawlings-Goss R., Hirbo J., Thompson S., Woldemeskel D., Froment Alain, Omar S. A., Bodo J. M., Nyambo T., Belay G., Drayna D., Breslin P. A. S., Tishkoff S. A. (2014). Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa. Journal of Human Genetics, 59 (6), p. 349-352. ISSN 1434-5161.
Titre du document
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa
Année de publication
2014
Auteurs
Campbell M. C., Ranciaro A., Zinshteyn D., Rawlings-Goss R., Hirbo J., Thompson S., Woldemeskel D., Froment Alain, Omar S. A., Bodo J. M., Nyambo T., Belay G., Drayna D., Breslin P. A. S., Tishkoff S. A.
Source
Journal of Human Genetics, 2014,
59 (6), p. 349-352 ISSN 1434-5161
Bitter taste perception, mediated by receptors encoded by the TAS2R loci, has important roles in human health and nutrition. Prior studies have demonstrated that nonsynonymous variation at site 516 in the coding exon of TAS2R16, a bitter taste receptor gene on chromosome 7, has been subject to positive selection and is strongly correlated with differences in sensitivity to salicin, a bitter anti-inflammatory compound, in human populations. However, a recent study suggested that the derived G-allele at rs702424 in the TAS2R16 promoter has also been the target of recent selection and may have an additional effect on the levels of salicin bitter taste perception. Here, we examined alleles at rs702424 for signatures of selection using Extended Haplotype Homozygosity (EHH) and F-ST statistics in diverse populations from West Central, Central and East Africa. We also performed a genotype-phenotype analysis of salicin sensitivity in a subset of 135 individuals from East Africa. Based on our data, we did not find evidence for positive selection at rs702424 in African populations, suggesting that nucleotide position 516 is likely the site under selection at TAS2R16. Moreover, we did not detect a significant association between rs702424 alleles and salicin bitter taste recognition, implying that this site does not contribute to salicin phenotypic variance. Overall, this study of African diversity provides further information regarding the genetic architecture and evolutionary history of a biologically-relevant trait in humans.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Développement scientifique et technique [116]
Description Géographique
AFRIQUE
Localisation
Fonds IRD [F B010062320]
Identifiant IRD
fdi:010062320
