@article{fdi:010062074,
  title = {{F}unctional antibodies against {VAR}2{CSA} in nonpregnant populations from {C}olombia exposed to {P}lasmodium falciparum and {P}lasmodium vivax},
  author = {{G}nidehou, {S}. and {D}oritchamou, {J}. and {A}rango, {E}. {M}. and {C}abrera, {A}. and {A}rroyo, {M}. {I}. and {K}ain, {K}. {C}. and {T}uikue {N}dam, {N}icaise and {M}aestre, {A}. and {Y}anow, {S}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n pregnancy, parity-dependent immunity is observed in response to placental infection with {P}lasmodium falciparum. {A}ntibodies recognize the surface antigen, {VAR}2{CSA}, expressed on infected red blood cells and inhibit cytoadherence to the placental tissue. {I}n most settings of malaria endemicity, antibodies against {VAR}2{CSA} are predominantly observed in multigravid women and infrequently in men, children, and nulligravid women. {H}owever, in {C}olombia, we detected antibodies against multiple constructs of {VAR}2{CSA} among men and children with acute {P}. falciparum and {P}lasmodium vivax infection. {T}he majority of men and children (> 60%) had high levels of {I}g{G}s against three recombinant domains of {VAR}2{CSA}: {DBL}5 epsilon, {DBL}3{X}, and {ID}1-{ID}2. {S}urprisingly, these antibodies were observed only in pregnant women, men, and children exposed either to {P}. falciparum or to {P}. vivax. {M}oreover, the anti-{VAR}2{CSA} antibodies are of high avidity and efficiently inhibit adherence of infected red blood cells to chondroitin sulfate {A} in vitro, suggesting that they are specific and functional. {T}hese unexpected results suggest that there may be genotypic or phenotypic differences in the parasites of this region or in the host response to either {P}. falciparum or {P}. vivax infection outside pregnancy. {T}hese findings may hold significant clinical relevance to the pathophysiology and outcome of malaria infections in this region.},
  keywords = {{COLOMBIE}},
  booktitle = {},
  journal = {{I}nfection and {I}mmunity},
  volume = {82},
  numero = {6},
  pages = {2565--2573},
  ISSN = {0019-9567},
  year = {2014},
  DOI = {10.1128/iai.01594-14},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062074},
}