@article{fdi:010062002,
  title = {{T}he transcriptional signatures of {S}odalis glossinidius in the {G}lossina palpalis gambiensis flies negative for {T}rypanosoma brucei gambiense contrast with those of this symbiont in tsetse flies positive for the parasite : possible involvement of a {S}odalis-hosted prophage in fly {T}rypanosoma refractoriness ?},
  author = {{S}oumana, {I}. {H}. and {L}oriod, {B}. and {R}avel, {S}ophie and {T}chicaya, {B}. and {S}imo, {G}. and {R}ihet, {P}. and {G}eiger, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{T}setse flies, such as {G}lossina palpalis gambiensis, are blood-feeding insects that could be subverted as hosts of the parasite {T}rypanosoma brucei gambiense: initiated in the tsetse fly mid gut, the developmental program of this parasite further proceeds in the salivary glands. {T}he flies act as vectors of this human-invasive parasite when their salivary glands sustain the generation of metacyclic trypomastigotes, the exclusive morphotypes pre-programmed to further develop in the human individuals. {B}riefly, once the metacyclic trypomastigotes have been deposited in the skin of humans from whom the parasite-hosting tsetse flies are taking their blood meals, the complex developmental program of this {T}rypanosoma brucei subspecies can result in a severe disease named sleeping sickness. {U}nveiling the processes that could prevent, in tsetse flies, the developmental program of {T}. b. gambiense could contribute reducing the prevalence of the disease. {U}sing a global approach, we were curious to extract transcriptional signatures of {S}odalis glossinidius, a symbiont hosted by three distinct groups of tsetse flies. {T}o meet this objective, the transcriptome of {S}. glossinidius from susceptible and refractory tsetse flies was analyzed at 3, 10 and 20 days after flies blood feed on {T}. b. gambiense-hosting mice. {W}ithin this temporal window, 176 trypanosome responsive genes were shown to interact in well-defined patterns making it possible to distinguish flies susceptible to the parasite infection from refractory flies. {A}mong the modulated transcripts in the symbiont population of flies refractory to trypanosome infection many were shown to cluster within the following networks: "lysozyme activity, bacteriolytic enzyme, bacterial cytolysis, cell wall macromolecule catabolic process". {T}hese novel data are further delineated in the following questions: could the activation of prophage hosted by {S}. glossinidius lead to the release of bacterial agonists that trigger the tsetse fly immune system along a profile that no more allows the parasite developmental program? ({C}) 2014 {E}lsevier {B}.{V}. {A}ll rights reserved.},
  keywords = {{S}odalis glossinidius ; {T}setse fly ; {T}rypanosoma brucei gambiense ; {T}ripartite interactions ; {B}acteriophage ; {R}efractoriness ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {24},
  numero = {},
  pages = {41--56},
  ISSN = {1567-1348},
  year = {2014},
  DOI = {10.1016/j.meegid.2014.03.005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062002},
}