@article{fdi:010061979,
  title = {{V}iral aetiology influenza like illnesses in {S}anta {C}ruz, {B}olivia (2010-2012)},
  author = {{D}elangue, {J}. and {S}anchez, {Y}. {R}. and {P}iorkowski, {G}. and {B}essaud, {M}. and {B}aronti, {C}{\'e}cile and {T}hirion {P}errier, {L}aurence and {M}afayle, {R}. {L}. and {A}rdaya, {C}. {A}. and {A}guilera, {G}. {A}. and {G}uzman, {J}. {R}. and {R}iera, {J}. {L}. and de {L}amballerie, {X}avier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}cute respiratory infections represent a serious public health issue worldwide but virological aetiologies of {I}nfluenza {L}ike {I}llnesses ({ILI}s) remain largely unknown in developing countries. {T}his study represents the first attempt to characterise viral aetiologies of {ILI}s in {B}olivia. {M}ethods: {I}t was performed in {S}anta {C}ruz city from {J}anuary 2010 to {S}eptember 2012, based on 564 naso pharyngeal swabs collected in a {N}ational {R}eference {L}aboratory and real-time {PCR} techniques, viral cultures and phylogenetic analyses. {R}esults: 50.2% of samples were positive for at least one virus with influenza viruses ({F}lu {A}: similar to 15%; {F}lu {B}: similar to 9%), rhinoviruses (similar to 8%), coronaviruses (similar to 5%) and h{RSV} (similar to 4%) being the most frequently identified. {T}he pattern of viral infections varied according to age groups. {T}he elucidation rate was the highest (>60%) amongst patients under 10 yo and the lowest (<40%) amongst patients >= 60 yo. {N}early 3% of samples showed dual viral infections. {E}pidemiological peaks were associated with a predominant virus but generally included 30-50% of infections by different viruses. {U}nexpectedly, the frequency of influenza in the 0-4 yo population was very low and a complete h{RSV} eclipse occurred in 2011. {G}enetic analyses indicated that distinct evolutionary lineages of {F}lu {A}({H}1{N}1)pdm2009, {F}lu {A}/{H}3{N}2 and {F}lu {B} have co-circulated in {B}olivia in the study period, originating from {C}entral and {N}orth {A}merica, {E}urope, {A}sia and {A}ustralia. {C}onclusion: {O}ur results emphasise the requirement for a reinforced epidemiological and genetic follow-up of influenza and other {ILI}s in {B}olivia to further inform the preparation of vaccines used in the region, guide vaccination campaigns and improve the medical management of patients.},
  keywords = {{E}pidemiology ; {I}nfluenza like illness ; {B}olivia ; {S}outh {A}merica ; {I}nfluenza ; {A}({H}1{N}1)pdm2009 ; {I}nfluenza phylogeny ; {R}espiratory infections ; {BOLIVIE}},
  booktitle = {},
  journal = {{V}irology {J}ournal},
  volume = {11},
  numero = {},
  pages = {art. 35},
  ISSN = {1743-422{X}},
  year = {2014},
  DOI = {10.1186/1743-422x-11-35},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061979},
}