@article{fdi:010061956,
  title = {{A} {TAL} effector repeat architecture for frameshift binding},
  author = {{R}ichter, {A}. and {S}treubel, {J}. and {B}lucher, {C}. and {S}zurek, {B}oris and {R}eschke, {M}. and {G}rau, {J}. and {B}och, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}ranscription activator-like effectors ({TALE}s) are important {X}anthomonas virulence factors that bind {DNA} via a unique tandem 34-amino-acid repeat domain to induce expression of plant genes. {S}o far, {TALE} repeats are described to bind as a consecutive array to a consecutive {DNA} sequence, in which each repeat independently recognizes a single {DNA} base. {T}his modular protein architecture enables the design of any desired {DNA}-binding specificity for biotechnology applications. {H}ere we report that natural {TALE} repeats of unusual aminoacid sequence length break the strict one repeat-to-one base pair binding mode and introduce a local flexibility to {TALE}-{DNA} binding. {T}his flexibility allows {TALE}s and {TALE} nucleases to recognize target sequence variants with single nucleotide deletions. {T}he flexibility also allows {TALE}s to activate transcription at allelic promoters that otherwise confer resistance to the host plant.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {5},
  numero = {},
  pages = {art. 3447},
  ISSN = {2041-1723},
  year = {2014},
  DOI = {10.1038/ncomms4447},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061956},
}