%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Constantin de Magny, Guillaume
%A Hasan, N. A.
%A Roche, Benjamin
%T How community ecology can improve our understanding of cholera dynamics
%D 2014
%L fdi:010061892
%G ENG
%J Frontiers in Microbiology
%@ 1664-302X
%K cholera ; ecology ; metagenomics ; genetics ; pathogen
%M ISI:000333604900001
%P art. 137
%R 10.3389/fmicb.2014.00137
%U https://www.documentation.ird.fr/hor/fdi:010061892
%> https://www.documentation.ird.fr/intranet/publi/2014/05/010061892.pdf
%V 5
%W Horizon (IRD)
%X Understanding the seasonal emergence and reemergence of cholera is challenging due to the complex dynamics of different protagonists. The abundance of Vibrio cholerae, the causative agent of cholera and a natural inhabitant of aquatic environments, fluctuates according to abiotic, and biotic factors. Among the biotic factors, the zooplankton community dynamics has been suggested to play a pivotal role in the survival, persistence, and natural competence of V cholerae. However, factors regulating V cholerae population structure and seasonal dynamics are still not fully understood. Investigation of the temporal shifts and variability in aquatic community composition in relation to the occurrence or abundance of V cholerae appears very promising yet remained underexplored. Recent advances in metagenomics, facilitated by high-throughput ultra deep sequencing, have greatly improved our ability for a broader and deeper exploration of microbial communities including an understanding of community structure, function, as well as inter- and intra-specific competitions. Here, we discuss possible areas of research focusing how combination of community ecology and metagenomic approaches could be applied to study the cholera system.
%$ 052 ; 084 ; 036