@article{fdi:010061885,
  title = {{I}ntestinal parasitic infections in {HIV}-infected patients, {L}ao people's {D}emocratic {R}epublic},
  author = {{P}aboriboune, {P}. and {P}houmindr, {N}. and {B}orel, {E}. and {S}ourinphoumy, {K}. and {P}haxayaseng, {S}. and {L}uangkhot, {E}. and {S}engphilom, {B}. and {V}ansilalom, {Y}. and {O}dermatt, {P}. and {D}elaporte, {E}ric and {E}tard, {J}ean-{F}ran{\c{c}}ois and {R}abodonirina, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {HIV} infection is an emerging problem in {L}aos. {W}e conducted the first prospective study on intestinal parasites, including opportunistic protozoa, in newly diagnosed {HIV} infected patients, with or without diarrhea. {T}he aims were to describe the spectrum of infections, to determine their prevalence and to assess their associations with diarrhea, {CD}4 cell count, place of residence and living conditions. {M}ethodology: {O}ne to three stool samples over consecutive days were obtained from 137 patients. {T}he {K}ato thick smear method, formalin-ethyl concentration and specific stains for coccidia and microsporidia diagnosis were performed on 260 stool samples. {B}aseline characteristics regarding relevant demographics, place of residence and living conditions, clinical features including diarrhea, were collected using a standardized questionnaire. {P}rincipal {F}indings: {T}he 137 patients were young (median age: 36 years) and severely immunocompromised (83.9% at {WHO} stage 3 or 4, median {CD}4 cell count: 41/mm(3)). {D}iarrhea was present in 43.0% of patients. {P}arasite infection was found in 78.8% of patients, infection with at least two species in 49.6%. {P}revalence rates of protozoan and helminth infections were similar (54.7% and 58.4% respectively). {B}lastocystis sp. was the most frequent protozoa (26.3%). {C}ryptosporidium sp., {C}ytoisospora belli and microsporidia, found at low prevalence rates (6.6%, 4.4%, 2.9%, respectively), were described for the first time in {L}aos. {C}ryptosporidium sp. was associated with persistent diarrhea. {S}trongyloides stercoralis was the most prevalent helminth following {O}pisthorchis viverrini (20.4% and 47.5% respectively). {T}he most immunocompromised patients, as assessed by a {CD}4 count <= 50 cells/mm(3), were more likely to be infected with intestinal parasites. {C}onclusions/{S}ignificance: {HIV} infection was mainly diagnosed at an advanced stage of immunosuppression in {L}ao patients. {I}ntestinal parasite infections were highly prevalent regardless of their diarrheal status. {O}pportunistic infections were reported. {I}mproving the laboratory diagnosis of intestinal parasite infections and the knowledge on their local risk factors is warranted.},
  keywords = {{LAOS}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {3},
  pages = {e91452},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0091452},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061885},
}