@article{fdi:010061879,
  title = {{P}atterns of selection on {P}lasmodium falciparum erythrocyte-binding antigens after the colonization of the {N}ew {W}orld},
  author = {{Y}alcindag, {E}. and {R}ougeron, {V}. and {E}lguero, {E}ric and {A}rnathau, {C}. and {D}urand, {P}. and {B}risse, {S}. and {D}iancourt, {L}. and {A}ubouy, {A}gn{\`e}s and {B}ecquart, {P}ierre and d'{A}lessandro, {U}. and {F}ontenille, {D}idier and {G}amboa, {D}. and {M}aestre, {A}. and {M}enard, {D}. and {M}usset, {L}. and {N}oya, {O}. and {V}eron, {V}. and {W}ide, {A}. and {C}arme, {B}. and {L}egrand, {E}. and {C}hevillon, {C}. and {A}yala, {F}. {J}. and {R}enaud, {F}. and {P}rugnolle, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{P}athogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. {D}uring its colonization of {S}outh {A}merica from {A}frica, {P}lasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations ({A}merindian and populations of mixed origins) that likely exerted new selective pressures on the parasite's genome. {A}mong the genes that might have experienced strong selective pressures in response to these environmental changes, the eba genes (erythrocyte-binding antigens genes), which are involved in the invasion of the human red blood cells, constitute good candidates. {I}n this study, we analysed, in {S}outh {A}merica, the polymorphism of three eba genes (eba-140, eba-175, eba-181) and compared it to the polymorphism observed in {A}frican populations. {T}he aim was to determine whether these genes faced selective pressures in {S}outh {A}merica distinct from what they experienced in {A}frica. {P}atterns of genetic variability of these genes were compared to the patterns observed at two housekeeping genes (adsl and serca) and 272 {SNP}s to separate adaptive effects from demographic effects. {W}e show that, conversely to {A}frica, eba-140 seemed to be under stronger diversifying selection in {S}outh {A}merica than eba-175. {I}n contrast, eba-181 did not show any sign of departure from neutrality. {T}hese changes in the patterns of selection on the eba genes could be the consequence of changes in the host immune response, the host receptor polymorphisms and/or the ability of the parasite to silence or express differentially its invasion proteins.},
  keywords = {adaptation ; balancing selection ; malaria ; co-evolution ; invasion ; {AMERIQUE} {DU} {SUD}},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {23},
  numero = {8},
  pages = {1979--1993},
  ISSN = {0962-1083},
  year = {2014},
  DOI = {10.1111/mec.12696},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061879},
}