@article{fdi:010061855,
  title = {{I}mpact of long-lasting, insecticidal nets on anaemia and prevalence of {P}lasmodium falciparum among children under five years in areas with highly resistant malaria vectors},
  author = {{T}okponnon, {F}. {T}. and {O}gouyemi, {A}. {H}. and {S}issinto, {Y}. and {S}ovi, {A}. and {G}nanguenon, {V}. and {C}orn{\'e}lie, {S}ylvie and {A}deothy, {A}. {A}. and {O}sse, {R}. and {W}akpo, {A}. and {G}benou, {D}. and {O}ke, {M}. and {K}inde-{G}azard, {D}. and {K}leinschmidt, {I}. and {A}kogbeto, {M}. {C}. and {M}assougbodji, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he widespread use of insecticide-treated nets ({LLIN}s) leads to the development of vector resistance to insecticide. {T}his resistance can reduce the effectiveness of {LLIN} based interventions and perhaps reverse progress in reducing malaria morbidity. {T}o prevent such difficulty, it is important to know the real impact of resistance in the effectiveness of mosquito nets. {T}herefore, an assessment of {LLIN} efficacy was conducted in malaria prevention among children in high and low resistance areas. {M}ethods: {T}he study was conducted in four rural districts and included 32 villages categorized as low or high resistance areas in {P}lateau {D}epartment, south-western {B}enin. {L}arvae collection was conducted to measure vector susceptibility to deltamethrin and knockdown resistance (kdr) frequency. {I}n each resistance area, around 500 children were selected to measure the prevalence of malaria infection as well as the prevalence of anaemia associated with the use of {LLIN}s. {R}esults: {O}bserved mortalities of {A}nopheles gambiae s. s population exposed to deltamethrin ranged from 19 to 96%. {K}nockdown resistance frequency was between 38 and 84%. {T}he prevalence of malaria infection in children under five years was 22.4% (19.9-25.1). {T}his prevalence was 17.3% (14.2-20.9) in areas of high resistance and 27.1% (23.5-31.1) in areas of low resistance (p = 0.04). {E}ight on ten children that were aged six - 30 months against seven on ten of those aged 31-59 months were anaemic. {T}he anaemia observed in the six to 30-month old children was significantly higher than in the 31-59 month old children (p = 0.00) but no difference associated with resistance areas was observed (p = 0.35). {T}he net use rate was 71%. {T}he risk of having malaria was significantly reduced (p < 0.05) with {LLIN} use in both low and high resistance areas. {T}he preventive effect of {LLIN}s in high resistance areas was 60% (95% {CI}: 40-70), and was significantly higher than that observed in low resistance areas (p < 0.05). {C}onclusion: {T}he results of this study showed that the resistance of malaria vectors seems to date not have affected the impact of {LLIN}s and the use of {LLIN}s was highly associated with reduced malaria prevalence irrespective of resistance.},
  keywords = {{M}alaria ; {P}revalence of {P}lasmodium falciparum ; {A}naemia ; {R}esistance ; {LLIN}s ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {13},
  numero = {},
  pages = {art. 76 [11 ]},
  ISSN = {1475-2875},
  year = {2014},
  DOI = {10.1186/1475-2875-13-76},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061855},
}