%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Gaayeb, L.
%A Sarr, J. B.
%A Cames, Cécile
%A Pincon, C.
%A Hanon, J. B.
%A Ndiath, M. O.
%A Seck, M.
%A Herbert, F.
%A Sagna, A. B.
%A Schacht, A. M.
%A Remoué, Franck
%A Riveau, G.
%A Hermann, E.
%T Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal
%D 2014
%L fdi:010061845
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K SENEGAL
%M ISI:000332352900027
%N 3
%P 566-573
%R 10.4269/ajtmh.12-0657
%U https://www.documentation.ird.fr/hor/fdi:010061845
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010061845.pdf
%V 90
%W Horizon (IRD)
%X To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. A relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time. Moreover, a whole-blood stimulation assay highlighted that the production of interferon-gamma (IFN-gamma) in response to tetanus toxoid was compromised in stunted children. However, the absence of cytokine modulation in response to Mycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce IFN-gamma was preserved in stunted children. Therefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus.
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