@article{fdi:010061845,
  title = {{E}ffects of malnutrition on children's immunity to bacterial antigens in {N}orthern {S}enegal},
  author = {{G}aayeb, {L}. and {S}arr, {J}. {B}. and {C}ames, {C}{\'e}cile and {P}incon, {C}. and {H}anon, {J}. {B}. and {N}diath, {M}. {O}. and {S}eck, {M}. and {H}erbert, {F}. and {S}agna, {A}. {B}. and {S}chacht, {A}. {M}. and {R}emou{\'e}, {F}ranck and {R}iveau, {G}. and {H}ermann, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in {S}enegalese children ages 1-9 years old. {A} linear regression analysis predicted that weight for age was positively associated with immunoglobulin {G} ({I}g{G}) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. {A} relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time. {M}oreover, a whole-blood stimulation assay highlighted that the production of interferon-gamma ({IFN}-gamma) in response to tetanus toxoid was compromised in stunted children. {H}owever, the absence of cytokine modulation in response to {M}ycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce {IFN}-gamma was preserved in stunted children. {T}herefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {90},
  numero = {3},
  pages = {566--573},
  ISSN = {0002-9637},
  year = {2014},
  DOI = {10.4269/ajtmh.12-0657},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061845},
}